AiPD: Autoinhibited Protein Database

Gene name	ISPG (CLB4, CSB3, HDS, At5g60600, MUP24.2)
Protein name	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic
Names	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, Protein CHLOROPLAST BIOGENESIS 4, Protein CONSTITUTIVE SUBTILISIN 3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G60600
EC number	1.17.7.1: With an iron-sulfur protein as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

17-110 (Predicted disordered autoinhibitory region) PR

17-110 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-F4K0E8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_24359485_C_G	13	I>M	No	1000Genomes
tmp_5_24359528_C_G	28	L>V	No	1000Genomes
tmp_5_24359541_G_C	32	C>S	No	1000Genomes
tmp_5_24359576_G_C	44	V>L	No	1000Genomes
tmp_5_24359589_G_A	48	R>Q	No	1000Genomes
ENSVATH03458519	53	G>S	No	1000Genomes
ENSVATH00745161	67	P>R	No	1000Genomes
ENSVATH12878275	85	R>M	No	1000Genomes
tmp_5_24359784_A_T	85	R>W	No	1000Genomes
tmp_5_24359817_G_T	96	A>S	No	1000Genomes
tmp_5_24359827_G_C	99	S>T	No	1000Genomes
ENSVATH14642684	155	V>A	No	1000Genomes
ENSVATH00745164	172	T>S	No	1000Genomes
ENSVATH07456040	204	T>S	No	1000Genomes
ENSVATH12878282	374	A>P	No	1000Genomes
tmp_5_24361288_A_G	380	H>R	No	1000Genomes
ENSVATH07456047	388	R>P	No	1000Genomes
tmp_5_24361315_G_A	389	R>Q	No	1000Genomes
tmp_5_24361924_G_A	466	R>H	No	1000Genomes
ENSVATH07456051	491	L>F	No	1000Genomes
ENSVATH12878285	511	L>R	No	1000Genomes
ENSVATH03458528	524	D>N	No	1000Genomes
tmp_5_24362415_T_A	572	F>I	No	1000Genomes
tmp_5_24362431_A_T	577	H>L	No	1000Genomes
tmp_5_24362434_T_C	578	I>T	No	1000Genomes
ENSVATH03458530	596	Y>N	No	1000Genomes
ENSVATH00745171	725	G>C	No	1000Genomes
tmp_5_24363251_G_T	735	D>Y	No	1000Genomes
tmp_5_24363257_C_G	737	P>A	No	1000Genomes
ENSVATH00745172	740	D>N	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for F4K0E8

		Description
EC Number	1.17.7.1	With an iron-sulfur protein as acceptor
Subcellular Localization	Plastid, chloroplast stroma
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope	The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast stroma	The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
plastid	Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

Name	Definition
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity	Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.
iron ion binding	Binding to an iron (Fe) ion.

Name	Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
systemic acquired resistance, salicylic acid mediated signaling pathway	The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance.
terpenoid biosynthetic process	The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins