F4JTE7
Gene name |
GPP1 |
Protein name |
(DL)-glycerol-3-phosphatase 1, mitochondrial |
Names |
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase, AtGpp1/PyrP3, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate phosphatase, ARPP phosphatase, Glycerol-1-phosphatase 1, AtGPP1, Haloacid dehalogenase-like hydrolase domain-containing protein GPP1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G25840 |
EC number |
3.1.3.21: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4JTE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4JTE7-F1 | Predicted | AlphaFoldDB |
38 variants for F4JTE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_13139069_T_A | 15 | F>Y | No | 1000Genomes | |
| ENSVATH00538367 | 25 | I>S | No | 1000Genomes | |
| tmp_4_13139126_G_A | 34 | R>Q | No | 1000Genomes | |
| ENSVATH12228046 | 35 | K>R | No | 1000Genomes | |
| tmp_4_13139131_C_A | 36 | P>T | No | 1000Genomes | |
| ENSVATH12228047 | 37 | V>A | No | 1000Genomes | |
| tmp_4_13139138_T_G | 38 | I>S | No | 1000Genomes | |
| tmp_4_13139144_T_C | 40 | V>A | No | 1000Genomes | |
| tmp_4_13139143_G_T | 40 | V>F | No | 1000Genomes | |
| tmp_4_13139150_C_T | 42 | A>V | No | 1000Genomes | |
| tmp_4_13139152_A_G | 43 | S>G | No | 1000Genomes | |
| ENSVATH02924128 | 55 | A>V | No | 1000Genomes | |
| tmp_4_13139192_C_T | 56 | A>V | No | 1000Genomes | |
| ENSVATH02924129 | 58 | N>D | No | 1000Genomes | |
| ENSVATH06775570 | 60 | T>P | No | 1000Genomes | |
| ENSVATH06775570 | 60 | T>S | No | 1000Genomes | |
| tmp_4_13139239_A_G | 72 | T>A | No | 1000Genomes | |
| tmp_4_13139275_G_A | 84 | D>N | No | 1000Genomes | |
| ENSVATH14296353 | 87 | K>N | No | 1000Genomes | |
| ENSVATH12228052 | 96 | I>V | No | 1000Genomes | |
| tmp_4_13139605_T_G | 101 | N>K | No | 1000Genomes | |
| tmp_4_13139693_A_T | 131 | S>C | No | 1000Genomes | |
| ENSVATH06775575 | 131 | S>T | No | 1000Genomes | |
| tmp_4_13139696_G_T | 132 | D>Y | No | 1000Genomes | |
| tmp_4_13139711_G_C | 137 | E>Q | No | 1000Genomes | |
| ENSVATH14296354 | 142 | E>D | No | 1000Genomes | |
| tmp_4_13140023_C_G | 177 | A>G | No | 1000Genomes | |
| tmp_4_13140200_G_T | 193 | R>L | No | 1000Genomes | |
| tmp_4_13140208_T_C | 196 | F>L | No | 1000Genomes | |
| tmp_4_13140226_G_A | 202 | V>I | No | 1000Genomes | |
| tmp_4_13140232_C_T | 204 | R>W | No | 1000Genomes | |
| tmp_4_13140255_G_T | 211 | K>N | No | 1000Genomes | |
| tmp_4_13140277_G_A | 219 | G>S | No | 1000Genomes | |
| ENSVATH06775580 | 235 | R>S | No | 1000Genomes | |
| ENSVATH06775581 | 244 | P>S | No | 1000Genomes | |
| tmp_4_13140595_T_C | 258 | I>T | No | 1000Genomes | |
| ENSVATH00538374 | 263 | S>P | No | 1000Genomes | |
| ENSVATH00538374 | 263 | S>T | No | 1000Genomes |
No associated diseases with F4JTE7
No regional properties for F4JTE7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4JTE7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.21 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity | Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. |
| glycerol-1-phosphatase activity | Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. |
| glycerol-3-phosphatase activity | Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate. |
| metal ion binding | Binding to a metal ion. |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dephosphorylation | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. |
| glycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| riboflavin biosynthetic process | The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q94529 | Gs1l | Probable pseudouridine-5'-phosphatase | Drosophila melanogaster (Fruit fly) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTTPTRFVA | LRIPFRSSNK | IPISIAPSPK | VFPRKPVIRV | PASLRFVATM | STPAAAVNAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTVTDAGRGS | ITHVIFDMDG | LLLDTEKFYT | EVQEKILARY | NKTFDWSLKA | KMMGRKAIEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARLFVDESGI | SDSLSAEDFI | VERESMLQDL | FPTSDLMPGA | SRLLRHLHGK | GIPICIATGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HTRHFDLKTQ | RHRELFSLMH | HVVRGDDPEV | KEGKPAPDGF | LAASRRFEDG | PVDPRKVLVF |
| 250 | 260 | 270 | 280 | 290 | |
| EDAPSGVQAA | KNAGMNVIMV | PDSRLDKSYC | NVADQVLASL | LDFKPEEWGL | PSFQDSHN |