F4IZC5

PR
Gene name
CAN1 (CAN, At3g56170, F18O21.130)
Protein name
Staphylococcal-like nuclease CAN1
Names
Calcium-dependent nuclease 1, AtCAN1, Ca(2+)-dependent nuclease 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G56170
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

122-205 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4IZC5

Entry ID Method Resolution Chain Position Source
AF-F4IZC5-F1 Predicted AlphaFoldDB

19 variants for F4IZC5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_20842627_T_C 5 I>T No 1000Genomes
tmp_3_20842659_G_A 16 G>S No 1000Genomes
ENSVATH14442480 42 E>V No 1000Genomes
ENSVATH12789213 49 V>L No 1000Genomes
ENSVATH06325280 76 P>A No 1000Genomes
tmp_3_20843132_C_T 86 A>V No 1000Genomes
ENSVATH12789214 95 V>I No 1000Genomes
ENSVATH06325283 103 G>R No 1000Genomes
tmp_3_20843330_T_C 119 V>A No 1000Genomes
tmp_3_20843342_A_C 123 K>T No 1000Genomes
tmp_3_20843363_A_G 130 N>S No 1000Genomes
tmp_3_20843527_G_T 156 V>L No 1000Genomes
tmp_3_20843939_A_G 229 E>G No 1000Genomes
tmp_3_20843964_G_A 237 M>I No 1000Genomes
tmp_3_20844075_A_C 274 K>N No 1000Genomes
tmp_3_20844229_T_A 294 N>K No 1000Genomes
tmp_3_20844309_G_A 321 G>E No 1000Genomes
tmp_3_20844308_G_A 321 G>R No 1000Genomes
tmp_3_20844311_G_C 322 G>R No 1000Genomes

No associated diseases with F4IZC5

2 regional properties for F4IZC5

Type Name Position InterPro Accession
active_site Thermonuclease active site 251 - 261 IPR002071
domain Staphylococcal nuclease (SNase-like), OB-fold 130 - 306 IPR016071

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
metal ion binding Binding to a metal ion.
nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
nucleic acid binding Binding to a nucleic acid.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2QUS0 Os12g0255200 Probable staphylococcal-like nuclease CAN4 Oryza sativa subsp japonica (Rice) PR
Q2RBJ2 Os11g0109500 Probable staphylococcal-like nuclease CAN2 Oryza sativa subsp japonica (Rice) PR
Q2QYR1 Os12g0109200 Probable staphylococcal-like nuclease CAN3 Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MGNAIRLLRK CLNSHGVSAS SGGVSALSRD LLNFETTSQV PEKLGSYVVS SQKAQANWYR
70 80 90 100 110 120
KILEAWKQAK PRPKTPEEAS RLVIAALKNH QKADVEGLLS FYGLPSPHNL VEVPTEAPVS
130 140 150 160 170 180
LPKGVRFELN TLPVDTKSVA DGDTVTVYVS SKDPLVSSSL PKDVSLAAVK RAKAREKKNY
190 200 210 220 230 240
TEADALHKTI IASGYRMISF QNEEVLAKKF RIRLSGIDSP ESKMPYGKEA HDELLKMVEG
250 260 270 280 290 300
KCLKVLVYTE DRYGRCVGDI YCNGKFVQEV MLKKGLAWHY VAYDKRAELA KWENEARQKR
310 320
VGLWASSNPE KPWEWRKNKR GGN