F4I366

PR
Gene name
NRPA2
Protein name
DNA-directed RNA polymerase I subunit 2
Names
DNA-directed RNA polymerase I subunit RPA2, DNA polymerase I subunit A2, Nuclear RNA polymerase A2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G29940
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

770-843 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4I366

Entry ID Method Resolution Chain Position Source
AF-F4I366-F1 Predicted AlphaFoldDB

51 variants for F4I366

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04669500 4 N>K No 1000Genomes
ENSVATH01126039 12 T>S No 1000Genomes
ENSVATH12326674 38 L>I No 1000Genomes
tmp_1_10486541_G_C 44 R>G No 1000Genomes
ENSVATH14001818 47 P>T No 1000Genomes
tmp_1_10486519_T_C 51 Y>C No 1000Genomes
ENSVATH12326673 60 S>T No 1000Genomes
ENSVATH04669493 86 L>F No 1000Genomes
ENSVATH00050824 95 I>V No 1000Genomes
ENSVATH12326670 100 T>M No 1000Genomes
tmp_1_10486180_C_T 102 M>I No 1000Genomes
ENSVATH04669479 136 K>N No 1000Genomes
tmp_1_10485794_T_C 150 T>A No 1000Genomes
ENSVATH00050821 179 S>G No 1000Genomes
tmp_1_10485130_G_A 207 S>L No 1000Genomes
ENSVATH04669460 248 D>E No 1000Genomes
tmp_1_10484742_G_C 255 L>V No 1000Genomes
tmp_1_10484625_G_A 294 R>C No 1000Genomes
ENSVATH12326594 296 Q>H No 1000Genomes
ENSVATH00050819 299 K>N No 1000Genomes
ENSVATH12326591 319 I>S No 1000Genomes
ENSVATH12326591 319 I>T No 1000Genomes
ENSVATH14001780 323 A>V No 1000Genomes
tmp_1_10484150_G_C 337 H>D No 1000Genomes
tmp_1_10483997_A_G 359 L>S No 1000Genomes
ENSVATH04669447 401 L>M No 1000Genomes
ENSVATH04669445 408 F>Y No 1000Genomes
tmp_1_10483424_T_G 420 I>L No 1000Genomes
tmp_1_10483379_A_T 435 L>M No 1000Genomes
tmp_1_10482448_G_A 528 S>F No 1000Genomes
ENSVATH14001776 529 K>Q No 1000Genomes
ENSVATH04669426 532 I>V No 1000Genomes
ENSVATH14001775 614 S>R No 1000Genomes
tmp_1_10482100_A_G 615 M>T No 1000Genomes
ENSVATH00050806 632 I>V No 1000Genomes
tmp_1_10482041_C_T 635 V>I No 1000Genomes
tmp_1_10481774_C_T 696 D>N No 1000Genomes
ENSVATH04669415 733 Q>L No 1000Genomes
tmp_1_10480894_A_T 806 F>Y No 1000Genomes
ENSVATH04669402 819 K>N No 1000Genomes
ENSVATH04669401 820 A>T No 1000Genomes
tmp_1_10480653_T_C 851 T>A No 1000Genomes
ENSVATH00050802 912 L>S No 1000Genomes
tmp_1_10480376_C_T 918 M>I No 1000Genomes
tmp_1_10480363_C_G 923 V>L No 1000Genomes
ENSVATH12325753 972 K>E No 1000Genomes
tmp_1_10479997_G_A 991 S>F No 1000Genomes
tmp_1_10479995_T_A 992 M>L No 1000Genomes
ENSVATH12325752 1003 T>S No 1000Genomes
tmp_1_10479524_T_C 1112 Q>R No 1000Genomes
tmp_1_10479349_T_A 1170 L>F No 1000Genomes

No associated diseases with F4I366

7 regional properties for F4I366

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 688 - 1058 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 896 - 908 IPR007121
domain RNA polymerase Rpb2, domain 7 1060 - 1169 IPR007641
domain RNA polymerase Rpb2, domain 2 192 - 371 IPR007642
domain RNA polymerase, beta subunit, protrusion 21 - 411 IPR007644
domain RNA polymerase Rpb2, domain 3 459 - 522 IPR007645
domain DNA-directed RNA polymerase I subunit RPA2, domain 4 576 - 633 IPR009674

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
metal ion binding Binding to a metal ion.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
megagametogenesis The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVNAKDSTV PTMEDFKELH NLVTHHIESF DYMTLKGLDV MFNRIKPVSV YDPNTENELS
70 80 90 100 110 120
IWLENPLVFA PQKESFKSTS RKEPLLPFEC RQAKISYTGT FMADVCFKYN DGVVVRDKFD
130 140 150 160 170 180
FGQFPIMLMS KLCSLKGADC RKLLKCKEST SEMGGYFILN GIERVFRCVI APKRNHPTSM
190 200 210 220 230 240
IRNSFRDRKE GYSSKAVVTR CVRDDQSSVT VKLYYLRNGS ARVGFWIVGR EYLLPVGLVL
250 260 270 280 290 300
KALTNSCDEE IYESLNCCYS EHYGRGDGAI GTQLVRERAK IILDEVRDLG LFTREQCRKH
310 320 330 340 350 360
LGQHFQPVLD GVKKESLSIV AEAVLRDYLF VHLDNDHDKF NLLIFIIQKL YSLVDQTSLP
370 380 390 400 410 420
DNPDSLQNQE ILVPGHVITI YLKEKLEEWL RKCKSLLKDE LDNTNSKFSF ESLADVKKLI
430 440 450 460 470 480
NKNPPRSIGT SIETLLKTGA LKTQSGLDLQ QRAGYTVQAE RLNFLRFLSF FRAVHRGASF
490 500 510 520 530 540
AGLRTTTVRK LLPESWGFLC PVHTPDGTPC GLLNHMTRTS RITSQFDSKG NIRDFLKIRK
550 560 570 580 590 600
SVVDVLTGAG MVPSLPKLVR AGPPKVIHVL LDGQVVGTLS SNLVTKVVSY IRRLKVEAPS
610 620 630 640 650 660
VIPEDLEVGY VPTSMGGSYP GLYLASCPAR FIRPVKNISI PSDNIELIGP FEQVFMEISC
670 680 690 700 710 720
PDGGNGGRNN SSLATHEEIH PTGMISVVAN LTPWSDHNQS PRNMYQCQMA KQTMAYSTQA
730 740 750 760 770 780
LQFRADQKIY HLQTPQSPVV RTKTYTTYSI DENPTGTNAI VAVLAHTGFD MEDAMILNKS
790 800 810 820 830 840
SVERGMCHGQ IYQTENIDLS DQNSRFDSGS KSFRRSTNKA EHFRIDADGL PSVGQKLYPD
850 860 870 880 890 900
EPYCSIYDEV TNKTRHMKRK GTDPVIVDFV SVDMKSKKHP QRANIRFRHA RNPIIGDKFS
910 920 930 940 950 960
SRHGQKGVCS QLWPDIDMPF NGVTGMRPDL IINPHAFPSR MTIAMLLESI AAKGGSLHGK
970 980 990 1000 1010 1020
FVDATPFRDA VKKTNGEEES KSSLLVDDLG SMLKEKGFNH YGTETLYSGY LGVELKCEIF
1030 1040 1050 1060 1070 1080
MGPVYYQRLR HMVSDKFQVR STGQVDQLTH QPIKGRKRGG GIRFGEMERD SLLAHGASYL
1090 1100 1110 1120 1130 1140
LHDRLHTSSD HHIADVCSLC GSLLTSSVVN VQQKKLIQEI GKLPPGRTPK KVTCYSCKTS
1150 1160 1170
KGMETVAMPY VFRYLAAELA SMNIKMTLQL SDREGVTD