| diet induced thermogenesis |
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system. |
| energy homeostasis |
Any process involved in the balance between food intake (energy input) and energy expenditure. |
| glucose metabolic process |
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. |
| HRI-mediated signaling |
A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. |
| integrated stress response signaling |
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. |
| lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| mitochondrial protein processing |
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. |
| mitochondrial respiratory chain complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. |
| negative regulation of mitochondrial fusion |
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. |
| positive regulation of apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| protein autoprocessing |
Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. |
| protein quality control for misfolded or incompletely synthesized proteins |
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
| proteolysis involved in protein catabolic process |
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. |
| regulation of cristae formation |
Any process that modulates the frequency, rate or extent of cristae formation. |
| zymogen activation |
The proteolytic processing of an inactive enzyme to an active form. |
