E9AIE8
Gene name |
LBRM_20_5150 |
Protein name |
Acireductone dioxygenase |
Names |
Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD |
Species |
Leishmania braziliensis |
KEGG Pathway |
lbz:LBRM_20_5150 |
EC number |
1.13.11.53: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for E9AIE8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-E9AIE8-F1 | Predicted | AlphaFoldDB |
No variants for E9AIE8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for E9AIE8 | |||||
No associated diseases with E9AIE8
1 regional properties for E9AIE8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain-containing protein 17-like domain | 218 - 308 | IPR010357 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.53 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| acireductone dioxygenase (Ni2+-requiring) activity | Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate. |
| acireductone dioxygenase [iron(II)-requiring] activity | Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+). |
| iron ion binding | Binding to an iron (Fe) ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| L-methionine salvage from methylthioadenosine | The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTECWYIPEE | VADRREENRL | SPNVPGSYEA | LSEARVFFRH | FDPKEVSDDI | EGFIQPLLKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNYHSYDVVN | LSPATLGDEK | FEALAEQHFM | EHTHEDDEVR | LILEGQGYFD | VRDANDKWIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLSKPGDCIV | LPAGMYHRFT | TDHSKCIKTL | RIFKEAPRWI | ALNRGPETEE | KPARKEYLAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LHAPAETAVG | AANSHTIFSL | HYPLKLDAEL | TVITKRLLEQ | HSKQPLALMI | FLTGSTDPTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GASWCPDCIP | AKPQVAQRFA | ELQGKYGEER | AIFLQLPVER | AGYLGNPEYP | YRKHPTLQLA |
| 310 | 320 | 330 | 340 | ||
| SVPTLLVLTP | TKDAKEKGDV | QWYDRLEVKM | RTCDIDKADV | LSLE |