E7FHC4

PR
Gene name
shyA
Protein name
Sulfhydrogenase 2 subunit alpha
Names
Hydrogen dehydrogenase (NAD(P)(+)), Hydrogenase-II subunit alpha, H-II alpha, NADP-reducing hydrogenase subunit ShyA, Sulfhydrogenase II subunit alpha
Species
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
KEGG Pathway
pfu:PF1332
EC number
1.12.1.5: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E7FHC4

Entry ID Method Resolution Chain Position Source
AF-E7FHC4-F1 Predicted AlphaFoldDB

No variants for E7FHC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E7FHC4

No associated diseases with E7FHC4

1 regional properties for E7FHC4

Type Name Position InterPro Accession
binding_site Nickel-dependent hydrogenase, large subunit, nickel binding site 399 - 408 IPR018194

Functions

Description
EC Number 1.12.1.5 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ferredoxin hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2.
hydrogen dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + H2 = NADPH + H+.
hydrogen dehydrogenase activity Catalysis of the reaction: H2 + NAD+ = H+ + NADH.
nickel cation binding Binding to a nickel (Ni) cation.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIELDEFTR VEGNGKAEIV IENGEVKDAR VKIVEGPRFF EILTLGRDYW DVPDLEARIC
70 80 90 100 110 120
AICYIAHSVA SVRAIEKALG IDVPESVEKL RELALWGEII ESHALHLYLL ALPDVFGYPD
130 140 150 160 170 180
AISMIPRHGE LVKEGLTIKA FGNAIRELIG GREIHGINIK PGGFGRYPSE EELEKIAEHS
190 200 210 220 230 240
KSLIKFARRI VGIFASQEAG GAVGEVLMAT SDYLWGDELI INGERVQYYE VDEVPVGYSF
250 260 270 280 290 300
AKHSYYKGNP VFVGALPRLL LKGESIEGEA ARMLEEYRDK LESKYVIYNN LAQAIELLYA
310 320 330 340 350 360
LERVPQLVEE ILSEGIERGN GEISQESGEG VGYVEAPRGV LVHHYRIENG KVVWSNTITP
370 380 390 400 410
TAFNQRLMEL SLLEEAKRLY GSESEENMKK RLEVIVRAFD PCISCSVHFV KL