E2IUK4

PR
Gene name
HORMAD1
Protein name
HORMA domain-containing protein 1
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100499502
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-383 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E2IUK4

Entry ID Method Resolution Chain Position Source
AF-E2IUK4-F1 Predicted AlphaFoldDB

No variants for E2IUK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E2IUK4

No associated diseases with E2IUK4

1 regional properties for E2IUK4

Type Name Position InterPro Accession
domain HORMA domain 24 - 226 IPR003511

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis
  • TRIP13 is required for depletion from synapsed chromosomes
  • The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

9 GO annotations of biological process

Name Definition
blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
meiotic DNA double-strand break formation The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.
meiotic recombination checkpoint signaling A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
meiotic sister chromatid cohesion The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
regulation of homologous chromosome segregation Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
synaptonemal complex assembly The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATAQLQRTS MSALVFPNKI STEQQSLVLV KRLLAVSVSC ITYLRGIFPE CAYGTRYLDD
70 80 90 100 110 120
LCVKILREDK NCPGSTQLVK WMLGCYDALQ KKYLRMVVLA VYTNPEDPQT ISECYQFKFK
130 140 150 160 170 180
YTSNGPIMDF ISKNQSSESS MSSADTKKAS ILLIRKIYIL MQNLGPLPND VCLTMKLFYY
190 200 210 220 230 240
DEVTPPDYQP PGFKDGDCEG VIFEGEPMYL NVGEVPTPFH TFKVKVTTEK ERMENIYSGI
250 260 270 280 290 300
LSPKQIKTPL QKILMDKDDL EDEQEHYIND DFDIETKMEE QKKKLGSSEL GEPNLVCEED
310 320 330 340 350 360
EIMRSKESPE LSISHSQVEQ LVSKTSELDV SESKTRSGKI FQNKMANGNQ QIKSKESRKR
370 380 390
SQLESGKTVL HHFDSSSQDS VPKRRKFSEP KEHI