Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for E2IHA6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-E2IHA6-F1 | Predicted | AlphaFoldDB |
No variants for E2IHA6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for E2IHA6 | |||||
No associated diseases with E2IHA6
5 regional properties for E2IHA6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 53 - 305 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 171 - 183 | IPR008271 |
| domain | Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain | 328 - 385 | IPR013896 |
| binding_site | Protein kinase, ATP binding site | 59 - 82 | IPR017441 |
| domain | AMPK, C-terminal adenylate sensor domain | 487 - 613 | IPR032270 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLPKHLKFA | AGAGGAFLFG | ILFGWVMFPA | ILKGQLKKEM | ALSKKTDVRK | MWETIPFALN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKVYLYNYTN | PEEVQKGGVP | IIKEVGPYHF | DEWKEKVEIE | DHEEDDTITY | KKRDTFYFNQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKSGPGLTGE | EVITMPHVFM | LAMATVVSRE | KPAMMNMIGK | AINGIFDNPA | DVFIRVKALD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IMFRGTMINC | ARTEFAPKAV | CTALKKEAVN | GLVMEPNNQF | RFSLFGSRNG | TIDPHVVTVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RGIKNVMDVG | QVVAIDGKPQ | QDVWRDHCNE | YQGTDGTVFP | PFLTEHDRLQ | SFSGDLCRSF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPWYQKKSFY | RGITTHRYIA | NIGDFANDPE | LNCFCDGPCP | PKGLMDLMKC | MKAPMYASMP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HFLDSDPELL | KNVKGLNPDV | NEHGIEIDFE | PISGTPMVAN | QRVQFNMQLL | KHDKVELLNN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPDTIVPLFW | IDEGLALNKT | FVNMLKFQLF | YPKKAVGVIK | WLLVTFGGFG | LIGCTIYHYK |
| 490 | 500 | 510 | 520 | ||
| DRIMSFASSP | GSAAVTKVKP | EEVEQKDVSV | IGQPQEPAKI | NM |