E1BGH8

PR
Gene name
MMS22L
Protein name
Protein MMS22-like
Names
Methyl methanesulfonate-sensitivity protein 22-like
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

656-731 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E1BGH8

Entry ID Method Resolution Chain Position Source
AF-E1BGH8-F1 Predicted AlphaFoldDB

No variants for E1BGH8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E1BGH8

No associated diseases with E1BGH8

2 regional properties for E1BGH8

Type Name Position InterPro Accession
domain MMS22-like, C-terminal 849 - 1224 IPR029424
domain Protein MMS22-like, N-terminal 26 - 729 IPR029425

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Localizes to DNA damage sites, accumulates at stressed replication forks
  • Recruited to stalled or collapsed replication forks; directly binds replication protein A complex (RPA/RP-A)-coated single-stranded DNA (ssDNA)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
site of DNA damage A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

1 GO annotations of molecular function

Name Definition
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
replication fork processing The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDNCPPASTF LTDSLELELQ TEWCNPPCFS CDFDNRGGGK HFSGESYLSS GALKRVILNL
70 80 90 100 110 120
DPLPTNFEED TVEIFGIEWV TETALVNSSR VLFHLFRQQL YNLETLLQAS CDFGKISTLH
130 140 150 160 170 180
CKAHNIRQLC VTFLHYVKVF IFRSLQVRNA ESHVPVHPYE TLEAQLPSVL VDELHGLLLY
190 200 210 220 230 240
IGHLSELPTT NTGAFVNQNQ TKLYPPSWHL LHLHLDIHWL VLEILHMLGE KLKQVVYSHQ
250 260 270 280 290 300
FMNLAGDNLT NVSLFEEHCE NLLCDLINLS LNRYDKKVRP SEALMSHHCP CPCIKELWVL
310 320 330 340 350 360
LIHLLNHRSK WSLSESFWNW LNKLLKTLLE KSNDQRRSVL IVQPRDPLGF SWWIITHVAS
370 380 390 400 410 420
FYQFDRHGTP DEMRQMESNW NFVEELLKKS ISVQDGILEE QLRMYLHCCL TLCDFWEPNI
430 440 450 460 470 480
AIVTILWEYY SKNLNSSFSI SWLPLKGLTY IIKSPLSMLE MVKTCCCDKQ DHDLYKSSSS
490 500 510 520 530 540
YTIFLCILAK VVKKAMKNNG PHPWKQVKGR IYSKFHQKRM EELTEVGLQN FFSLFLLLAA
550 560 570 580 590 600
VAEVEDVASH VLRLLDFLKP TFKTSPLIWK GQMAFLLMYT QKNLDIGVLA EKFSNAFREK
610 620 630 640 650 660
AKEFLVSKND EMGQRQTLWT LLSIYMDSVQ EVFETSRCLH PSHEKLLNDG FSMLLRACQE
670 680 690 700 710 720
SELRTVLNFL QAVLARIRSL HQQLRQELQR EHGDLSVQSS LSTKERHLAA VASALWRHFF
730 740 750 760 770 780
SFLKSQRMSQ IVPLSQLADA AADFTLLAMD LPSTAPSDLQ PQPVTSMIQL FGWDDIIWPQ
790 800 810 820 830 840
VVARYLSHFL QNSMLCEALS HSGCVSFQAL TVRSWIRCIL QMYVKNLHVP DDSFIDINPE
850 860 870 880 890 900
QAVEKDYMEQ LTELTRLLFK LSEVKNIFSK SQVELPIPDD PKKALIRFFE AVGITYGNLQ
910 920 930 940 950 960
TVSDKSAMVT KSLEYLGEIL KYIKPYLGKK VSSAGLQLTY TMMGTLVKSW ALIFATSKAQ
970 980 990 1000 1010 1020
KLLFRIIDCL LLPHTVLQQE KELPAPMLTA IQKSLPLYLQ GMCIVCCQSQ NTNAYLNQLL
1030 1040 1050 1060 1070 1080
GNVIEQYIGR FLPASAHVLG LGQHPVLLAL KNSASVPPMS LLKKCIVHVI RKSYFEFKGS
1090 1100 1110 1120 1130 1140
LLPPRLASIL AFILQLVKET NTDVSEIELL LPGVLKCLLL VSEPQVKRLA TENLQCMVRA
1150 1160 1170 1180 1190 1200
CQVGSGGEPA AQLTSVFRQF IEDYGMRYDY QIYSILEAVA ALDQQVVIHL VPTLTQSLKN
1210 1220 1230 1240
SERKWGLGRN SAQREAYSKL LSQLGQVGQD EIQRLENDHI ESML