D6VTK4

PR
Gene name
STE2 (YFL026W)
Protein name
Pheromone alpha factor receptor
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YFL026W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-431 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for D6VTK4

Entry ID Method Resolution Chain Position Source
1PJD NMR - A 253-269 PDB
2K9P NMR - A 31-110 PDB
7AD3 EM 330 A A/B 9-306 PDB
7QA8 EM 270 A A/B 1-431 PDB
7QB9 EM 310 A A/B 1-431 PDB
7QBC EM 353 A A/B 1-431 PDB
7QBI EM 346 A A/B 1-431 PDB
AF-D6VTK4-F1 Predicted AlphaFoldDB

11 variants for D6VTK4

Variant ID(s) Position Change Description Diseaes Association Provenance
s06-82673 32 N>K No SGRP
s06-82677 34 S>T No SGRP
s06-83027 150 I>M No SGRP
s06-83103 176 A>T No SGRP
s06-83179 201 D>G No SGRP
s06-83231 218 M>I No SGRP
s06-83637 354 T>A No SGRP
s06-83658 361 E>K No SGRP
s06-83662 362 R>K No SGRP
s06-83685 370 D>N No SGRP
s06-83718 381 P>S No SGRP

No associated diseases with D6VTK4

No regional properties for D6VTK4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for D6VTK4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Internalized after binding of alpha-factor (PubMed:8392878)
  • STE2 enters the cell by receptor-mediated endocytosis and is continuously lost and resynthesized in the presence of alpha-factor (PubMed:1330324, PubMed:3015412, PubMed:7935439, PubMed:8392878)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
G protein-coupled receptor homodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
mating-type alpha-factor pheromone receptor activity Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity.
mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity.
pheromone binding Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.

3 GO annotations of biological process

Name Definition
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cytogamy During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT QAIMFGVRCG
70 80 90 100 110 120
AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK YLLSNYSSVT YALTGFPQFI
130 140 150 160 170 180
SRGDVHVYGA TNIIQVLLVA SIETSLVFQI KVIFTGDNFK RIGLMLTSIS FTLGIATVTM
190 200 210 220 230 240
YFVSAVKGMI VTYNDVSATQ DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ
250 260 270 280 290 300
FDSFHILLIM SCQSLLVPSI IFILAYSLKP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN
310 320 330 340 350 360
NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR RKETTSDKHS
370 380 390 400 410 420
ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK EGEVEPVDMY TPDTAADEEA
430
RKFWTEDNNN L