Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for D3ZK93
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5VHW | EM | 780 A | A/B/C/D | 2-238 | PDB |
| 5VHX | EM | 830 A | A/B/C/D/E | 2-238 | PDB |
| 5VHY | EM | 460 A | A/B/C/D/E/F | 2-238 | PDB |
| 5VHZ | EM | 840 A | A/B/C/D/E/F | 2-238 | PDB |
| AF-D3ZK93-F1 | Predicted | AlphaFoldDB |
2 variants for D3ZK93
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3319134435 | 35 | G>R | No | EVA | |
| rs3319131814 | 69 | A>V | No | EVA |
No associated diseases with D3ZK93
No regional properties for D3ZK93
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for D3ZK93 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| asymmetric synapse | A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of AMPA receptor activity | Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. |
| regulation of postsynaptic neurotransmitter receptor activity | Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. |
| regulation of postsynaptic neurotransmitter receptor internalization | Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTSRRGRAL | LAVALNLLAL | LFATTAFLTT | YWCQGTQRVP | KPGCGQGGGA | NCPNSGANAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ANSTAAPVAA | SPAGAPYSWE | AGDERFQLRR | FHTGIWYSCE | EELGGPGEKC | RSFIDLAPAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKGVLWLSVV | SEVLYILLLV | VGFSLMCLEL | LHSSSVIDGL | KLNAFAAVFT | VLSGLLGMVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HMMYTQVFQV | TVSLGPEDWR | PHSWDYGWSF | CLAWGSFTCC | MAASVTTLNS | YTKTVIEFRH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRKVFEQGYR | EEPTFIDPEA | IKYFRERIEK | GDVSEEEDFR | LACRHERYPT | RHQPHMGDSW |
| 310 | 320 | ||||
| PRSSAHEAAE | LNRQCWVLGH | WV |