D3E045

PR
Gene name
mtrA1
Protein name
Tetrahydromethanopterin S-methyltransferase subunit A 1
Names
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 1
Species
Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1) (Methanobacterium ruminantium)
KEGG Pathway
mru:mru_1919
EC number
2.1.1.86: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D3E045

Entry ID Method Resolution Chain Position Source
AF-D3E045-F1 Predicted AlphaFoldDB

No variants for D3E045

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D3E045

No associated diseases with D3E045

No regional properties for D3E045

Type Name Position InterPro Accession
No domain, repeats, and functional sites for D3E045

Functions

Description
EC Number 2.1.1.86 Methyltransferases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
cobalt ion binding Binding to a cobalt ion (Co).
tetrahydromethanopterin S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM.

4 GO annotations of biological process

Name Definition
methanogenesis, from carbon dioxide The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2).
methylation The process in which a methyl group is covalently attached to a molecule.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADKKPAADN WPVVSGDYIV GDPESPVAVT TLASHNEDIP AAAGAAIAGP CKTENLGIEK
70 80 90 100 110 120
VVANIISNPN IRFLILCGAE VQGHITGQSI QALHENGCDP EKKKITGATG AIPFVENIPM
130 140 150 160 170 180
EGVERFQQQV ELVDLIDNED GGAITAKVKE CIEKDPGAFE EDAMVIEVKE GDDDEDEGEE
190 200 210 220 230 240
IRPISAETAL LEARIRNIDT QVKLVGAVQR NMAGNYSGKV QGIMIGLIFT LVIGFLLLMA
PLLGA