D2NT93

PR
Gene name
pafA
Protein name
Pup--protein ligase
Names
Proteasome accessory factor A, Pup-conjugating enzyme
Species
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
KEGG Pathway
rmu:RMDY18_10370
EC number
6.3.1.19: Acid--ammonia (or amine) ligases (amide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

130-255 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for D2NT93

Entry ID Method Resolution Chain Position Source
AF-D2NT93-F1 Predicted AlphaFoldDB

No variants for D2NT93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for D2NT93

No associated diseases with D2NT93

No regional properties for D2NT93

Type Name Position InterPro Accession
No domain, repeats, and functional sites for D2NT93

Functions

Description
EC Number 6.3.1.19 Acid--ammonia (or amine) ligases (amide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
ubiquitin-like protein transferase activity Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.

3 GO annotations of biological process

Name Definition
modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
protein pupylation The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEHRIFGIES EFGLSYVPHG LGRLSIEESA AALFKPVLDQ WRSTNVFLPN GGRLYLDVGS
70 80 90 100 110 120
HPEYASAECG SIDELLAQER AGELLFADLA RTARKRLLAG SEGRPLDGEL YLFKNNVDSA
130 140 150 160 170 180
GNSYGSHENY LISRKLQFND LIAQLVPFLV TRQILVGAGK THPNGGPVPG STDPASSTGV
190 200 210 220 230 240
PSYSFSQRAD HIWEAASTST SRARPLINTR DEPHADASKF RRMHVINGDS NMAEPTTLLK
250 260 270 280 290 300
IASTDLVLRM LEDRFPVTSL DIVSVPAALR AISHDLTGTA TFETTDGKHY TALSVQRHYL
310 320 330 340 350 360
DAARQYVQQY GAHHHHVEYA LDLWQRTLDA IESGDYSSID SEIDWAIKKK LLDAYIARAR
370 380 390 400 410 420
AAGQPADYAS ARIRQLDLAY HDIDPERSVF HALVRRGAVK RILPEGAAEA AKTQPPNTRA
430 440 450 460 470 480
LQRSRFINAA VAAGEQFTVD WVHLKLNAYP QHTLVCKDPF ATDSEGLEEV LTLLEGKARQ
HQEAAFPPPC