AiPD: Autoinhibited Protein Database

C9J6K1

Gene name	C19orf81
Protein name	Putative uncharacterized protein C19orf81
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:342918
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-72 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for C9J6K1

Entry ID	Method	Resolution	Chain	Position	Source
AF-C9J6K1-F1	Predicted				AlphaFoldDB

194 variants for C9J6K1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs576562572 CA406989257	5	V>A		No	ClinGen TOPMed gnomAD
rs576562572 CA309615274	5	V>G		No	ClinGen TOPMed gnomAD
rs1181743515 CA406989297	7	P>L		No	ClinGen gnomAD
rs866422546 CA309615279	8	V>A		No	ClinGen TOPMed
CA309615277 rs893184611	8	V>L		No	ClinGen TOPMed gnomAD
CA406989302 rs893184611	8	V>M		No	ClinGen TOPMed gnomAD
CA309615284 rs775646984	13	M>L		No	ClinGen Ensembl
rs1010321930 CA309615287	13	M>T		No	ClinGen gnomAD
rs1462350556 CA406989459	16	P>L		No	ClinGen gnomAD
rs1050467280 CA309615289	16	P>S		No	ClinGen TOPMed
rs375741176 CA309615290	17	T>I		No	ClinGen Ensembl
rs780829258 CA9600706 CA309615294	18	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1433956835 CA406989492	18	M>T		No	ClinGen TOPMed
CA406989524 rs1421988997	19	H>Q		No	ClinGen gnomAD
CA9600707 rs748175897	19	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	20	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769851402 CA9600708	21	K>Q		No	ClinGen ExAC gnomAD
rs1599826482 CA406989564	22	A>E		No	ClinGen Ensembl
rs1479036211 CA406990601	23	G>E		No	ClinGen gnomAD
CA406990614 rs1424768203	24	A>D		No	ClinGen gnomAD
rs887436354 CA406990608	24	A>P		No	ClinGen gnomAD
CA309617201 rs887436354	24	A>S		No	ClinGen gnomAD
rs887436354 CA406990607	24	A>T		No	ClinGen gnomAD
CA406990610 rs1424768203	24	A>V		No	ClinGen gnomAD
CA309617204 rs542605854	27	M>T		No	ClinGen 1000Genomes TOPMed gnomAD
rs1036511187 CA309617207	28	D>Y		No	ClinGen TOPMed gnomAD
rs1258935569 CA406990680	29	L>P		No	ClinGen TOPMed
rs765677846 CA9600717	30	E>K		No	ClinGen ExAC gnomAD
rs192383921 CA309617212	31	T>I		No	ClinGen 1000Genomes TOPMed gnomAD
CA406990720 rs192383921	31	T>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs1419688962 CA406990724	32	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406990750 rs1464553855	33	E>G		No	ClinGen TOPMed
rs1189175389 CA406990809	35	M>I		No	ClinGen gnomAD
rs1366947045 CA406990822	36	Q>*		No	ClinGen TOPMed gnomAD
rs1436530363 CA406990835	36	Q>H		No	ClinGen gnomAD
CA406990818 rs1366947045	36	Q>K		No	ClinGen TOPMed gnomAD
CA406990845 rs1257264275	37	A>P		No	ClinGen gnomAD
CA9600719 rs185628472	38	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs558403135 CA9600718	38	R>W		No	ClinGen ExAC TOPMed gnomAD
rs540911652 CA9600720	39	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA406990905 rs1282176261	40	L>R		No	ClinGen TOPMed
rs1237931324 CA406990987	44	I>V		No	ClinGen gnomAD
rs778504965 CA309617228	45	K>R		No	ClinGen Ensembl
rs1007445473 CA309617231	47	S>L		No	ClinGen TOPMed gnomAD
TCGA novel	47	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs530632779 CA309617241	52	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
CA406991210 rs1353350473	52	R>W		No	ClinGen TOPMed gnomAD
CA406991259 rs1599829521	54	V>G		No	ClinGen Ensembl
rs117025012 CA9600726	54	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1177182398 CA406991264	55	I>V		No	ClinGen gnomAD
rs959581840 CA309617246	59	E>K		No	ClinGen TOPMed gnomAD
CA406991358 rs1226861586	59	E>V		No	ClinGen gnomAD
rs1411058885 CA406991442	62	D>G		No	ClinGen gnomAD
CA309617251 rs908824661	63	R>*		No	ClinGen TOPMed gnomAD
CA309617254 rs940324471	63	R>Q		No	ClinGen TOPMed gnomAD
rs1399123260 CA406991506	64	E>G		No	ClinGen gnomAD
CA406991489 rs1364412327	64	E>K		No	ClinGen TOPMed
rs991076028 CA309617256	65	L>F		No	ClinGen TOPMed gnomAD
rs991076028 CA406991519	65	L>I		No	ClinGen TOPMed gnomAD
CA406991557 rs1335945274	66	P>L		No	ClinGen gnomAD
rs749206263 CA9600727	67	C>Y		No	ClinGen ExAC gnomAD
CA406991590 rs1377117135	68	I>T		No	ClinGen TOPMed gnomAD
rs1258737240 CA406991613	69	R>Q		No	ClinGen TOPMed gnomAD
rs144243088 CA9600728	69	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1196909390 CA406991690	72	P>R		No	ClinGen gnomAD
rs4801844 CA9600729	77	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs4801844 CA406991766	77	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406991811 rs1236267677	79	P>L		No	ClinGen gnomAD
rs933065966 CA309617263	79	P>S		No	ClinGen gnomAD
CA406991800 rs933065966	79	P>T		No	ClinGen gnomAD
CA309617268 rs924409330	81	C>*		No	ClinGen TOPMed
rs148726014 CA309617271	84	M>V		No	ClinGen 1000Genomes TOPMed
rs1422206797 CA406991886	85	E>K		No	ClinGen gnomAD
rs1463800179 CA406991905	86	T>A		No	ClinGen gnomAD
CA9600735 rs773751385	88	P>S		No	ClinGen ExAC gnomAD
rs1420302321 CA406992366	90	E>K		No	ClinGen gnomAD
CA406992387 rs1270031961	91	D>G		No	ClinGen TOPMed
CA309617748 rs1027850544	91	D>N		No	ClinGen TOPMed gnomAD
rs766503302 CA9600737	93	T>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	94	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1331916551 CA406992484	98	L>M		No	ClinGen TOPMed gnomAD
rs1331916551 CA406992486	98	L>V		No	ClinGen TOPMed gnomAD
CA406992525 rs1024031878	100	A>D		No	ClinGen gnomAD
CA309617754 rs1024031878	100	A>V		No	ClinGen gnomAD
CA9600739 rs759810149	104	Q>*		No	ClinGen ExAC gnomAD
CA406992619 rs1568422081	106	P>L		No	ClinGen Ensembl
rs1211131965 CA406992636	108	A>T		No	ClinGen gnomAD
rs575466887 CA309617762	109	M>I		No	ClinGen 1000Genomes
CA309617760 rs748546582	109	M>T		No	ClinGen gnomAD
rs113399266 CA9600740	109	M>V		No	ClinGen ExAC TOPMed gnomAD
CA406992667 rs1283651855	110	E>K		No	ClinGen TOPMed
CA309617766 rs867833546	111	S>T		No	ClinGen Ensembl
CA406992722 rs1394190188	112	G>E		No	ClinGen TOPMed
CA406992711 rs1450688791	112	G>R		No	ClinGen TOPMed gnomAD
CA9600741 rs536402359	113	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs554798671 CA9600742	113	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs916582222 CA309617776	115	S>R		No	ClinGen TOPMed
CA406992778 rs1440052328	116	S>C		No	ClinGen gnomAD
CA406992776 rs1440052328	116	S>G		No	ClinGen gnomAD
CA406992822 rs1157785829	117	I>N		No	ClinGen gnomAD
rs1378431982 CA406992837	118	R>C		No	ClinGen gnomAD
CA406992842 rs777688296	118	R>H		No	ClinGen ExAC TOPMed gnomAD
rs777688296 CA9600743	118	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9600744 rs753884072	120	E>*		No	ClinGen ExAC gnomAD
CA309617783 rs1051165815	120	E>D		No	ClinGen Ensembl
rs753884072 CA406992872	120	E>K		No	ClinGen ExAC gnomAD
CA9600745 rs573114045	121	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9600746 rs778486214	122	M>I		No	ClinGen ExAC gnomAD
CA406992928 rs1393253220 CA406992920	122	M>L		No	ClinGen TOPMed gnomAD
rs1451024992 CA406992933	122	M>T		No	ClinGen Ensembl
rs942820982 CA309617790	124	V>I		No	ClinGen gnomAD
CA406993013 rs1261316931	125	I>M		No	ClinGen TOPMed
CA309617796 rs925383821	125	I>S		No	ClinGen TOPMed gnomAD
CA406993056 rs1308917823	127	G>E		No	ClinGen gnomAD
CA9600747 rs745311338	128	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1247536197 CA406993085	129	A>T		No	ClinGen gnomAD
CA406993099 rs1159657338	129	A>V		No	ClinGen gnomAD
CA309617802 rs1043922253	130	G>A		No	ClinGen TOPMed gnomAD
rs540313417 CA9600749	131	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs558395868 CA9600750	132	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1053002170 CA309617805	132	R>W		No	ClinGen TOPMed gnomAD
CA406993156 rs1457895447	133	N>D		No	ClinGen gnomAD
rs1177788313 CA406993166	133	N>K		No	ClinGen gnomAD
rs1236064956 CA406993176	134	R>L		No	ClinGen gnomAD
CA309617807 rs944254593	134	R>W		No	ClinGen TOPMed
CA406994025 rs1388427908	136	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs576875269 CA9600752	137	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1185910805 CA406994087	140	T>M		No	ClinGen TOPMed gnomAD
CA406994106 rs1478308231	141	D>E		No	ClinGen gnomAD
TCGA novel	141	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406994110 rs1170221127	142	F>L		No	ClinGen gnomAD
rs1018230174 CA309618044	144	T>A		No	ClinGen Ensembl
rs964029025 CA309618047	144	T>R		No	ClinGen TOPMed gnomAD
rs1467872749 CA406994175	146	S>L		No	ClinGen TOPMed gnomAD
CA406994178 rs1467872749	146	S>W		No	ClinGen TOPMed gnomAD
CA406994186 rs1378560973	147	R>C		No	ClinGen TOPMed
CA406994189 rs1178930503	147	R>H		No	ClinGen TOPMed
rs979470681 CA406994225	150	R>C		No	ClinGen gnomAD
rs1279618855 CA406994227	150	R>H		No	ClinGen gnomAD
CA309618053 rs979470681	150	R>S		No	ClinGen gnomAD
CA406994236 rs1417815260	152	G>R		No	ClinGen TOPMed
rs1292963340 CA406994258	154	S>G		No	ClinGen gnomAD
CA406994263 rs1313550997	154	S>N		No	ClinGen gnomAD
rs1210579849 CA406994280	155	P>S		No	ClinGen TOPMed gnomAD
CA406994275 rs1210579849	155	P>T		No	ClinGen TOPMed gnomAD
CA406994315 rs1179278618	157	G>E		No	ClinGen TOPMed
CA406994303 rs1255134364	157	G>R		No	ClinGen gnomAD
rs774504933 CA9600755	160	H>P		No	ClinGen ExAC TOPMed gnomAD
CA406994351 rs1203259810	160	H>Y		No	ClinGen TOPMed
CA309618060 rs1032818133	161	Q>H		No	ClinGen TOPMed gnomAD
CA309618065 rs563701623	162	I>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA406994394 rs1315006953	162	I>T		No	ClinGen TOPMed
rs1235367688 CA406994384	162	I>V		No	ClinGen TOPMed
CA9600756 rs759492228	163	V>M		No	ClinGen ExAC gnomAD
TCGA novel	164	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767601758 CA9600757	165	H>N		No	ClinGen ExAC TOPMed gnomAD
CA406994443 rs1435069671	165	H>Q		No	ClinGen gnomAD
rs767601758 CA309618069	165	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1177251657 CA406994460	166	D>E		No	ClinGen gnomAD
rs1599831243 CA406994470	167	D>A		No	ClinGen Ensembl
rs549756528 CA309618072	167	D>H		No	ClinGen TOPMed gnomAD
CA406994468 rs549756528	167	D>N		No	ClinGen TOPMed gnomAD
CA309618074 rs549756528	167	D>Y		No	ClinGen TOPMed gnomAD
COSM3357188 CA406994526 rs1360655871	171	G>D	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1300564726 CA406994521	171	G>R		No	ClinGen gnomAD
CA309618077 rs1028908851	172	D>Y		No	ClinGen TOPMed
rs1599831264 CA406994560	173	Y>S		No	ClinGen Ensembl
rs752910483 CA309618079	174	R>C		No	ClinGen ExAC TOPMed gnomAD
rs752910483 CA309618084	174	R>G		No	ClinGen ExAC TOPMed gnomAD
CA309618085 rs760965435	174	R>H		No	ClinGen ExAC TOPMed gnomAD
rs760965435 CA9600759	174	R>L		No	ClinGen ExAC TOPMed gnomAD
rs752910483 CA9600758	174	R>S		No	ClinGen ExAC TOPMed gnomAD
CA406994606 rs1462161507	176	H>P		No	ClinGen TOPMed gnomAD
CA406994613 rs1183268143	177	L>M		No	ClinGen TOPMed
rs1443175667 CA406994630	178	R>C		No	ClinGen TOPMed
rs755959661 CA309618086	179	R>C		No	ClinGen gnomAD
TCGA novel	182	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs908818056 CA406994664	182	V>F		No	ClinGen TOPMed gnomAD
rs908818056 CA309618087	182	V>L		No	ClinGen TOPMed gnomAD
CA309618088 rs949577078	183	R>W		No	ClinGen TOPMed gnomAD
rs1444410571 CA406994672	184	R>G		No	ClinGen gnomAD
CA406994675 rs1215173706	184	R>Q		No	ClinGen gnomAD
TCGA novel	184	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406994679 rs1489628154	185	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406994701 rs1452923418	188	E>Q		No	ClinGen gnomAD
rs377132289 CA9600761	189	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1400581788 CA406994749	191	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1390082492 CA406994752	192	A>T		No	ClinGen gnomAD
rs1599831337 CA406994761	192	A>V		No	ClinGen Ensembl
CA309618099 rs926890870	193	E>G		No	ClinGen TOPMed
CA406994788 rs1243652325	194	P>A		No	ClinGen TOPMed
rs936977545 CA309618102	197	E>K		No	ClinGen Ensembl
rs898203923 CA309618119	199	A>G		No	ClinGen TOPMed gnomAD
CA309618116 rs898203923	199	A>R		No	ClinGen TOPMed gnomAD

No associated diseases with C9J6K1

No regional properties for C9J6K1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for C9J6K1

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MQPEVEPVCF	PAMGSPTMHR	KAGALLMDLE	TPEEMQARSL	GRPIKSSKQY	LRQVIAEYEA
70	80	90	100	110	120
LDRELPCIRK	FPTPPASQPL	CLCMETLPEE	DFTHLEVLQA	LEAQLPGAME	SGRVSSIRFE
130	140	150	160	170	180
NMNVICGTAG	RRNRWLIAVT	DFQTRSRLLR	SGLSPRGLAH	QIVRHDDLLL	GDYRLHLRRS
190
LVRRRMLEAL	GAEPNEEA