C8ZE58
Gene name |
EC1118_1L7_3389g |
Protein name |
Leu3p |
Names |
|
Species |
Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) |
KEGG Pathway |
|
EC number |
|
Protein Class |
FINGER DOMAIN PROTEIN, PUTATIVE-RELATED (PTHR31845) |
Descriptions
Leu3p belongs to a family of proteins characterized by an N-terminal DNA binding domain of the Zn(II)2Cys6 binuclear cluster type. The mutations within the autoinhibitory region (604-741) are found to make Leu3p constitutively active.
Autoinhibitory domains (AIDs)
Target domain |
855-886 (Transactivation domain) |
Relief mechanism |
Ligand binding |
Assay |
Deletion assay, Mutagenesis experiment |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C8ZE58
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C8ZE58-F1 | Predicted | AlphaFoldDB |
No variants for C8ZE58
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C8ZE58 | |||||
No associated diseases with C8ZE58
1 regional properties for C8ZE58
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zn(2)Cys(6) fungal-type DNA-binding domain | 31 - 78 | IPR001138 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR31845 | FINGER DOMAIN PROTEIN, PUTATIVE-RELATED |
| PANTHER Subfamily | PTHR31845:SF21 | REGULATORY PROTEIN LEU3 |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| zinc ion binding | Binding to a zinc ion (Zn). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGRSDSVAT | SQSGSEMSHS | ETRNRTGMNA | RKRKFACVEC | RQQKSKCDAH | ERAPEPCTKC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKKNVPCILK | RDFRRTYKRA | RNEAIEKRFK | ELTRTLTNLT | SDEILKKIEE | EQEIVLDNSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FTKEKVKQLR | KSAFETTEIE | PRSYKTLRGE | PISYSTNRKH | TDSSPLTLLS | SSTNFDPVHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TNVMTDDQLK | CLPKSLGDVY | LSSSDIAELF | QEFATKYHQF | LPVVDLSKGA | ERIYHLSPCL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FWVILLIGLR | RKFWATDLMT | RLSVLVKSVL | SEITISPIIR | YTPSDKDEPV | LNVASVYSVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFLLYTFWPP | LTSSLSADTS | WNTIGTAMFQ | ALRVGLNCAG | FSKEYASANS | ELVNEQIRTW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ICCNVVSQTV | ASSFGFPAYV | SFDYLVISSI | RVPNSKSQVD | IPNELRQMAQ | IARFENQIVN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TMNSTPASVT | GMVSQEEKQP | LLHVLNQQLS | QLEISLEENN | LDDIRKFLLL | VAKVHLLTYY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FTDVTSQSAG | KSNGNIYEGS | YSIMELDTSF | ETKRGLVKVY | NAAVNFLIHA | NSMWEHDPTI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IKYFPGLFVL | NIWQSACIIS | KLIHSSLHSM | LDVNSGKKAY | NNAISLTFNA | SVLKYDMAYR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSGIMRSIWS | LFANMYDAWK | NDQKEGGGRL | NNDFNLGITI | KSRMSVNVFF | DCLYILKEKC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GMAKLERETK | VSTAYNVDEE | EEEDEDEEGE | EEEEEEELSS | KVLENMDSQQ | LRTRKFTNVR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HPEKKARKII | ETIPLDPNPI | NAGSTSSGSS | LTTPNSQVAN | TISYRGILNK | MSPREQLNHA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NLDSSVSTDI | KDTEAVNEPL | PIGRNAEHPA | NQPPLSITQM | QENTLPATQA | NSSLLETYPI |
| 850 | 860 | 870 | 880 | ||
| VQSNPVTTTI | KESPNSIMAG | WDNWESDMVW | RDVDILMNEF | AFNPKV |