C8VPJ1

PR
Gene name
guf1 (AN10315)
Protein name
Translation factor guf1, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase guf1, Ribosomal back-translocase
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN2512.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C8VPJ1

Entry ID Method Resolution Chain Position Source
AF-C8VPJ1-F1 Predicted AlphaFoldDB

No variants for C8VPJ1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C8VPJ1

No associated diseases with C8VPJ1

6 regional properties for C8VPJ1

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 466 - 551 IPR000640
domain Translational (tr)-type GTP-binding domain 64 - 244 IPR000795
domain Small GTP-binding protein domain 66 - 233 IPR005225
domain GTP-binding protein LepA, C-terminal 555 - 660 IPR013842
conserved_site Tr-type G domain, conserved site 103 - 118 IPR031157
domain Elongation factor 4, domain IV 468 - 547 IPR035654

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mitochondrial ribosome binding Binding to a mitochondrial ribosome.
ribosome binding Binding to a ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGCLQLARW LSAAPNWPAS SLLKAPGSSF ATRLFTTTSS YKAKGPSKVP MTDLEARISA
70 80 90 100 110 120
IPIERYRNFC IVAHVDHGKS TLSDRLLELT GTIKPGMNKQ VLDKLDVERE RGITVKAQTC
130 140 150 160 170 180
TMIYNHKGED YLLHLVDTPG HVDFRAEVSR SYASCGGALL LVDASQGIQA QTVANFYLAF
190 200 210 220 230 240
SQGLELIPVI NKVDLPSAEP ERALEQLEQS FELDTEDAVL VSAKTGLNVE QLLPTVVEKI
250 260 270 280 290 300
PAPIGDCKRP LRMLLVDSWY DSYKGVICLV RVFDGEVRAG QQVVSFATGI KYYVGEVGIQ
310 320 330 340 350 360
YPLETPQTVL RAGQVGYIFF NPGMKRSKEA KIGDTFTTVG SEKAVQPLPG FEEPKAMVFV
370 380 390 400 410 420
AAYPVDADHF EHLEDSINQL VLNDRSITVQ KESSEALGAG FRLGFLGTLH CSVFEDRLRQ
430 440 450 460 470 480
EHGASIIITP PSVPVKVVWK DGKEDIITNP NRFPDEDDVR MKVAELQEPY VMATLTFPDE
490 500 510 520 530 540
YLGTVIELCE ANRGEQKSLE YFTPTQVILK YELPLAQLVD DFFGKLKGGT KGYASLDYEE
550 560 570 580 590 600
SGWKPSNIVK LQLLVNKAPV DAVARLVHYS QTDRLGRQWV TKFKEHVDRQ LFEIIIQAAV
610 620 630 640 650 660
GKKIVARETV KPYRKDVLAK LHASDVSRRR KLLEKQKEGR KRLRAVGNVV IEHKAFQAFL
AK