C8V9Y5

PR
Gene name
mclA (AN8755)
Protein name
Methylisocitrate lyase, mitochondrial
Names
2-methylisocitrate lyase, mitochondrial
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C8V9Y5

Entry ID Method Resolution Chain Position Source
AF-C8V9Y5-F1 Predicted AlphaFoldDB

No variants for C8V9Y5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C8V9Y5

No associated diseases with C8V9Y5

2 regional properties for C8V9Y5

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 271 - 276 IPR018523
domain ICL/PEPM domain 130 - 313 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRSIPRRVP RRLPIFTTTA TAGGPSRLAQ RAFTCGYLRM SPSSLPPVQP PVSSTLPSDS
70 80 90 100 110 120
YQLLSTADKA GDAEDALYEQ QIKDVEAWWN SPRFEGIKRP YSAADVVSKR GSLQQTYPSS
130 140 150 160 170 180
LMARKLFNLL NERAAENKPV HTMGAIDPVQ MTQQAPNQEV LYVSGWACSS VLTTTNEVSP
190 200 210 220 230 240
DFGDYPYNTV PNQVQRLFKA QQLHDRKHWD ARRKMTPEQR KSTPYIDYMR PIIADGDTGH
250 260 270 280 290 300
GGLTAVLKLA KLFAENGAAA VHFEDQMHGG KKCGHLAGKV LVPIGEHINR LVATRFQWDM
310 320 330 340 350 360
MGVENLVIAR TDSESGKLLS SAIDVRDHEF ILGVTEESEP LAETLQAMER EGAAPSEIDA
370 380 390 400 410 420
FELDWVKRHK LVTFDEAVDA HLEAEGAPQA ARDAYKKRVK ENPDLSITRR RELANDYTKT
430 440 450 460 470 480
PVVWSCDIPR TREGFYHYRA GFPAATKRAK EFGPYADLLW VETGDPNVEK AAKLAGEVRA
490 500 510 520 530 540
ALPGKKLVYN LSPSFNWMGQ GFDEASLKSF IWDLAQHGFV LQLISLAGLH SGATITAELS
550 560 570 580 590 600
RAFKDEGMLA YVRLIQAREK ELGVDVLTHQ KWSGAPYMDG IVGAIQSGSS SSKSMGEGNT
EKGEFNPLVF