C7GQ65

PR
Gene name
CHO2 (C1Q_02471)
Protein name
Phosphatidylethanolamine N-methyltransferase
Names
PE methyltransferase, PEAMT, PEMT
Species
Saccharomyces cerevisiae (strain JAY291) (Baker's yeast)
KEGG Pathway
EC number
2.1.1.17: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C7GQ65

Entry ID Method Resolution Chain Position Source
AF-C7GQ65-F1 Predicted AlphaFoldDB

No variants for C7GQ65

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C7GQ65

No associated diseases with C7GQ65

No regional properties for C7GQ65

Type Name Position InterPro Accession
No domain, repeats, and functional sites for C7GQ65

Functions

Description
EC Number 2.1.1.17 Methyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
phosphatidylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSCKTTLSE MVGSVTKDRG TINVKARTRS SNVTFKPPVT HDMVRSLFDP TLKKSLLEKC
70 80 90 100 110 120
IALAIISNFF ICYWVFQRFG LQFTKYFFLV QYLFWRIAYN LGIGLVLHYQ SHYETLTNCA
130 140 150 160 170 180
KTHAIFSKIP HNKDANSNFS TNSNSFSEKF WNFIRKFCQY EIRSKMPKEY DLFAYPEEIN
190 200 210 220 230 240
VWLIFRQFVD LILMQDFVTY IIYVYLSIPY SWVQIFNWRS LLGVILILFN IWVKLDAHRV
250 260 270 280 290 300
VKDYAWYWGD FFFLEESELI FDGVFNISPH PMYSIGYLGY YGLSLICNDY KVLLVSVFGH
310 320 330 340 350 360
YSQFLFLKYV ENPHIERTYG DGTDSDSQMN SRIDDLISKE NYDYSRPLIN MGLSFNNFNK
370 380 390 400 410 420
LRFTDYFTIG TVAALMLGAI MNARFINLNY LFITVFVTKL VSWLFISTIL YKQSQSKWFT
430 440 450 460 470 480
RLFLENGYTQ VYSYEQWQFI YNYYLVLTYT LMIIYTGLQI WSNFSNINNS QLIFGLILVA
490 500 510 520 530 540
LQTWCDKETR LAISDFGWFY GDFFLSNYIS TRKLTSQGIY RYLNHPEAVL GVVGVWGTVL
550 560 570 580 590 600
MTNFAVTNII LAVLWTLTNF ILVKFIETPH VNKIYGKTKR VSGVGKTLLG LKPLRQVSDI
610 620 630 640 650 660
VNRIENIIIK SLVDESKNSN GGAELLPKNY QDNKEWNILI QEAMDSVATR LSPYCELKIE
670 680 690 700 710 720
NEQIETNFVL PTPVTLNWKM PIELYNGDDW IGLYKVIDTR ADREKTRVGS GGHWSATSKD
730 740 750 760 770 780
SYMNHGLRHK ESVTEIKATE KYVQGKVTFD TSLLYFENGI YEFRYHSGNS HKVLLISTPF
790 800 810 820 830 840
EISLPVLNTT TPELFEKDLT EFLTKVNVLK DGKFRPLGNK FFGMDSLKQL IKNSIGVELS
850 860
SEYMRRVNGD AHVISHRAWD IKQTLDSLA