C7C436

PR
Gene name
mcsA
Protein name
2-methylcitrate synthase, mitochondrial
Names
Methylcitrate synthase, (2S,3S)-2-methylcitrate synthase, Citrate synthase 2
Species
Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KEGG Pathway
EC number
2.3.3.5: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C7C436

Entry ID Method Resolution Chain Position Source
AF-C7C436-F1 Predicted AlphaFoldDB

No variants for C7C436

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C7C436

No associated diseases with C7C436

1 regional properties for C7C436

Type Name Position InterPro Accession
active_site Citrate synthase active site 350 - 362 IPR019810

Functions

Description
EC Number 2.3.3.5 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
2-methylcitrate synthase activity Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.

1 GO annotations of biological process

Name Definition
citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALNLTSSRR ALGSLKPLTR AAFSGVRGYA TAEPDLKATL REAIPAKREL LKKVKAHSNK
70 80 90 100 110 120
VLGEVKVENT LGGMRGLKAM VWEGSVLDAN EGIRFHGRTI KDCQKELPKG KTGTEMLPEA
130 140 150 160 170 180
MFWLLLTGQV PSVNQVRTFS RELAEKAQIP EFISKMLDNF PKDLHPMTQF AMAVSALNYE
190 200 210 220 230 240
SKFAKAYEQG LNKADYWEPT FDDCISLLAK LPTIAAKIYQ NAYRGGGALP AEVDLEQDWS
250 260 270 280 290 300
YNFAAMLGKG GKENENFQDL LRLYLALHGD HEGGNVSAHA THLVGSALSD PFLSYSAGLQ
310 320 330 340 350 360
GLAGPLHGLA AQEVLRWIIQ MKEAIPANYT EQDVNDYLWS TLNSGRVVPG YGHAVLRKPD
370 380 390 400 410 420
PRFEALMDYA AARPEIANDP VFQLVEKNSR IAPEVLKKHG KTKNPYPNVD SSSGVLFHHY
430 440 450 460 470
GFHETLYYTA TFGVSRGLGP LAQLIWDRAL GLPIERPKSI NLEGILKQVE GQ