C6XZB6

PR
Gene name
hepB (Phep_2408)
Protein name
Heparin and heparin-sulfate lyase
Names
Heparin lyase, Heparin-sulfate lyase, Heparinase II, HepII
Species
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3)
KEGG Pathway
phe:Phep_2408
EC number
4.2.2.7: Acting on polysaccharides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for C6XZB6

Entry ID Method Resolution Chain Position Source
2FUQ X-ray 215 A A/B 27-772 PDB
2FUT X-ray 230 A A/B 25-772 PDB
3E7J X-ray 210 A A/B 24-772 PDB
3E80 X-ray 235 A A/B/C 24-772 PDB
AF-C6XZB6-F1 Predicted AlphaFoldDB

No variants for C6XZB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6XZB6

No associated diseases with C6XZB6

2 regional properties for C6XZB6

Type Name Position InterPro Accession
domain Heparinase II, N-terminal 107 - 262 IPR032518
domain Heparinase II, C-terminal 686 - 772 IPR040925

Functions

Description
EC Number 4.2.2.7 Acting on polysaccharides
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

4 GO annotations of molecular function

Name Definition
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
heparin lyase activity Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends.
heparin-sulfate lyase activity Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
heparin catabolic process The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRQLYLYVI FVVVELMVFT TKGYSQTKAD VVWKDVDGVS MPIPPKTHPR LYLREQQVPD
70 80 90 100 110 120
LKNRMNDPKL KKVWADMIKM QEDWKPADIP EVKDFRFYFN QKGLTVRVEL MALNYLMTKD
130 140 150 160 170 180
PKVGREAITS IIDTLETATF KPAGDISRGI GLFMVTGAIV YDWCYDQLKP EEKTRFVKAF
190 200 210 220 230 240
VRLAKMLECG YPPVKDKSIV GHASEWMIMR DLLSVGIAIY DEFPEMYNLA AGRFFKEHLV
250 260 270 280 290 300
ARNWFYPSHN YHQGMSYLNV RFTNDLFALW ILDRMGAGNV FNPGQQFILY DAIYKRRPDG
310 320 330 340 350 360
QILAGGDVDY SRKKPKYYTM PALLAGSYYK DEYLNYEFLK DPNVEPHCKL FEFLWRDTQL
370 380 390 400 410 420
GSRKPDDLPL SRYSGSPFGW MIARTGWGPE SVIAEMKVNE YSFLNHQHQD AGAFQIYYKG
430 440 450 460 470 480
PLAIDAGSYT GSSGGYNSPH NKNFFKRTIA HNSLLIYDPK ETFSSSGYGG SDHTDFAAND
490 500 510 520 530 540
GGQRLPGKGW IAPRDLKEML AGDFRTGKIL AQGFGPDNQT PDYTYLKGDI TAAYSAKVKE
550 560 570 580 590 600
VKRSFLFLNL KDAKVPAAMI VFDKVVASNP DFKKFWLLHS IEQPEIKGNQ ITIKRTKNGD
610 620 630 640 650 660
SGMLVNTALL PDAANSNITS IGGKGKDFWV FGTNYTNDPK PGTDEALERG EWRVEITPKK
670 680 690 700 710 720
AAAEDYYLNV IQIADNTQQK LHEVKRIDGD KVVGVQLADR IVTFSKTSET VDRPFGFSVV
730 740 750 760 770
GKGTFKFVMT DLLPGTWQVL KDGKILYPAL SAKGDDGALY FEGTEGTYRF LR