C6WID8

PR
Gene name
prcB
Protein name
Proteasome subunit beta
Names
20S proteasome beta subunit, Proteasome core protein PrcB
Species
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)
KEGG Pathway
ami:Amir_2241
EC number
3.4.25.1: Threonine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6WID8

Entry ID Method Resolution Chain Position Source
AF-C6WID8-F1 Predicted AlphaFoldDB

No variants for C6WID8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6WID8

No associated diseases with C6WID8

No regional properties for C6WID8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for C6WID8

Functions

Description
EC Number 3.4.25.1 Threonine endopeptidases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.

1 GO annotations of molecular function

Name Definition
threonine-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

2 GO annotations of biological process

Name Definition
modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDNSSTGRYP AASLPPAYLR PGSSSFTDFL RAQAPELLPT ARSFPEGSVV QAAHGTTIVA
70 80 90 100 110 120
LTFKGGVVIA GDRRATMGNV IAQRDMKKVF VTDDYSAVGI AGTAGIAIEI VRLFAVELRH
130 140 150 160 170 180
YEKIEGVSLS LDGKANRLSG MVKGNLDAAL AGLAVVPLFV GYDTDAADPD RAGRIVSYDV
190 200 210 220 230 240
TGARFEETLG YQSVGSGSLF AKSALKKLYD PDADAEGAVR AAVEALYDAA DDDSATGGPD
250 260 270 280
LVRRIFPVVV TVTAEGAVHL PEERTSAIAE TVVEGRRARP AG