C6HRP6

PR
Gene name
GET3
Protein name
ATPase GET3
Names
Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3
Species
Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-238 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6HRP6

Entry ID Method Resolution Chain Position Source
AF-C6HRP6-F1 Predicted AlphaFoldDB

No variants for C6HRP6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6HRP6

No associated diseases with C6HRP6

1 regional properties for C6HRP6

Type Name Position InterPro Accession
domain Anion-transporting ATPase-like domain 27 - 333 IPR025723

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSTAMVSGD DSLEPTLQSL LDQKTLRWVF VGGKGGVGKT TTSCSLAIQL AKVRKSVLLI
70 80 90 100 110 120
STDPAHNLSD AFGQKFGKEA RLVDGFDNLS AMEIDPNGSI QDLLATGGDQ ADDPMAGLGL
130 140 150 160 170 180
GGMMQDLAFS IPGVDEAMSF AEVLKQVKSL SYEVIVFDTA PTGHTLRFLQ FPTVLEKALA
190 200 210 220 230 240
KLSQLSSQFG PMLNSILGAR GGLPGGQNLD EILSKMESLR ETIGEVNAQF KDADLTTFVC
250 260 270 280 290 300
VCIAEFLSLY ETERMIQELT SYQIDTHCIV VNQLLFPGKD SSCEQCKARR KMQKKYLNEI
310 320 330 340
EDLYEDFNVV RMPMLVEEVR GKEKLEKFSN MLVNPYVPPE E