C6DFY6

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Pectobacterium carotovorum subsp carotovorum (strain PC1)
KEGG Pathway
pct:PC1_1888
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

585-642 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6DFY6

Entry ID Method Resolution Chain Position Source
AF-C6DFY6-F1 Predicted AlphaFoldDB

No variants for C6DFY6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6DFY6

No associated diseases with C6DFY6

7 regional properties for C6DFY6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 318 - 528 IPR002314
domain TGS 1 - 61 IPR004095
domain Anticodon-binding 541 - 630 IPR004154
domain Aminoacyl-tRNA synthetase, class II 243 - 534 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 170 - 219 IPR012947
domain Threonine-tRNA ligase catalytic core domain 242 - 539 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 539 - 629 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVITLPDGS QRHYDHAVSP LDVALDIGPG LAKACIAGRV NGELVDASDK IDTDAQLAII
70 80 90 100 110 120
TAKDEAGLEI IRHSCAHLLG HAIKQLWPDT KMAIGPVIDN GFYYDVDIDR TLTQEDIELL
130 140 150 160 170 180
EKRMHELADT DYDVIKKKVS WQEARDAFAA RGETYKMAIL DENISRDDRP GLYHHEEYID
190 200 210 220 230 240
MCRGPHVPNM RFCHHFKLQK TSGAYWRGDS KNKMLQRIYG TAWADKKQLA SYLQRLEEAA
250 260 270 280 290 300
KRDHRKIGKQ LDLYHMQEEA PGMVFWHNDG WTIFRELEAF VRMKLKSYQY QEVKGPFMMD
310 320 330 340 350 360
RVMWEKTGHW ENYKEAMFTT SSENREYCIK PMNCPGHVQI FNQGLKSYRD LPLRMAEFGS
370 380 390 400 410 420
CHRNEPSGSL HGLMRVRGFT QDDAHIFCTE EQVRDEVNSC IKMVYDMYST FGFEKIVVKL
430 440 450 460 470 480
STRPEKRIGS DEMWDRAEAD LAAALTENNI EFDYQPGEGA FYGPKIEFTL HDCLDRAWQC
490 500 510 520 530 540
GTVQLDFSLP GRLNASYVGE SNERQVPVMI HRAILGSMER FIGILTEEFA GFFPTWLAPV
550 560 570 580 590 600
QVVIMNITDT QSDYVNELTR KLQEAGIRVK ADLRNEKIGF KIREHTLRRV PYMLVCGDKE
610 620 630 640
VEAGKVAVRT RRGKDLGSLD VSEVISKLQQ EIRSRSLHQL EE