C6A429

PR
Gene name
pyrH
Protein name
Uridylate kinase
Names
UK, Uridine monophosphate kinase, UMP kinase, UMPK
Species
Thermococcus sibiricus (strain DSM 12597 / MM 739)
KEGG Pathway
tsi:TSIB_1322
EC number
2.7.4.22: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

122-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6A429

Entry ID Method Resolution Chain Position Source
AF-C6A429-F1 Predicted AlphaFoldDB

No variants for C6A429

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6A429

No associated diseases with C6A429

1 regional properties for C6A429

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 1 - 202 IPR001048

Functions

Description
EC Number 2.7.4.22 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
UMP kinase activity Catalysis of the reaction: ATP + UMP = ADP + UDP.

2 GO annotations of biological process

Name Definition
'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRIVFDIGGS VLVPDEPDVK FIEEIAYQLT KISEDHEVAV VVGGGRVARE YIQAAKSFTP
70 80 90 100 110 120
NETFKDYIGI HITRANAMLL IAALREKAYP FVVSDFRKAW EVMQLKKIPI MGGTHPGHTT
130 140 150 160 170 180
DAVAALLAEY LQADLLVVIT NVDGVYDSDP KKNPNAKKLD RISTEKLVEI AMQSESKAGG
190 200 210 220
SGVVDALAAK FIQRGEIKTL IIGKDDARTL FDAIKGKHKG TLVEP