C6A1Y5

PR
Gene name
pcn
Protein name
DNA polymerase sliding clamp
Names
Proliferating cell nuclear antigen homolog, PCNA
Species
Thermococcus sibiricus (strain DSM 12597 / MM 739)
KEGG Pathway
tsi:TSIB_0565
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6A1Y5

Entry ID Method Resolution Chain Position Source
AF-C6A1Y5-F1 Predicted AlphaFoldDB

No variants for C6A1Y5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6A1Y5

No associated diseases with C6A1Y5

3 regional properties for C6A1Y5

Type Name Position InterPro Accession
domain Proliferating cell nuclear antigen, PCNA, N-terminal 3 - 109 IPR022648
domain Proliferating cell nuclear antigen, PCNA, C-terminal 144 - 245 IPR022649
conserved_site Proliferating cell nuclear antigen, PCNA, conserved site 35 - 58 IPR022659

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA polymerase processivity factor activity An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.

2 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPFEIVFDGA KEFADLIDTA SNLIDEAAFK IAEEGMSMRA MDPSRVVLLD LNLPASIFSK
70 80 90 100 110 120
YDIDGEETVG VNMDHFKKVL KRGKGKDILV LRKGEENFLE ITLEGTAKRT FRLPLIEVEE
130 140 150 160 170 180
LELDLPELPF TVRAVILGEV LKEAVKDASL VSDSIKFIAK ENEFIMKAEG ETQEVEIKLT
190 200 210 220 230 240
LEDEGLLDLN VEEETKSAYG VSYLADMAKG IGKADEVVLR FGNEMPLQMD YPIRDEGRLT
FLLAPRVEE