C6A0S4
Gene name |
pckG |
Protein name |
Phosphoenolpyruvate carboxykinase [GTP] |
Names |
PEP carboxykinase, PEPCK |
Species |
Thermococcus sibiricus (strain DSM 12597 / MM 739) |
KEGG Pathway |
tsi:TSIB_0151 |
EC number |
4.1.1.32: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C6A0S4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C6A0S4-F1 | Predicted | AlphaFoldDB |
No variants for C6A0S4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C6A0S4 | |||||
No associated diseases with C6A0S4
3 regional properties for C6A0S4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site | 268 - 276 | IPR018091 |
| domain | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain | 244 - 603 | IPR035077 |
| domain | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal | 29 - 239 | IPR035078 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.32 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| manganese ion binding | Binding to a manganese ion (Mn). |
| phosphoenolpyruvate carboxykinase (GTP) activity | Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| gluconeogenesis | The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTPEDYLKKR | LDPEQFEKIK | GIDNPELNEF | LAKYIELLNP | ARVFICTDSK | EDENYIRRRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IEYGEEKSLA | MEGHTIHYDG | YYDQARDKAR | TKILVPKGVE | IPFINTMDRE | KGLKEIHEIM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDIAKGKELF | VCFFVLGPKN | SVFTIPAVQL | TDSAYVAHSE | FILYRKGYEE | FKRLGREAKF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKFVHSAGEL | DERKTSKNID | KRRVYIDLEG | ETVYSANTQY | GGNTIGLKKL | AFRLTIKRAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEGWLSEHMF | LMRINGPNGR | KTYFTGAYPS | MCGKTSTAMI | SWENIVGDDL | TFIVDMKGEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RGANVEKGVF | GIIQGVNQED | DPIIWEVLHS | PNEIIFSNVL | VKDGKPYWNE | MGIPIPDEGE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NHSGKWWRGK | KDSEGNEISP | SHKNARFTVS | LDAFPNTDLE | ALETPCGVRV | GGMIFGGRDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DTWPPVREAF | DWAHGVITMG | AALESETTAA | TLGKEGVRAF | NPMAILDFLS | VHIGKYLKNY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LEFEKKLRIK | PKIFAVNYFL | REKDGKWLNH | KLDKSVWLKW | MELRVHGDVD | AIKTPVGYIP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KYEDLKRLFK | EVLNKDYSRE | DYEKQFVIRV | PEFLAKIERI | EKIYRDVGNI | PEELFKVLEE |
| 610 | 620 | ||||
| ERHRLIEAKE | KYGDYISPFK | FL |