C6A0N1

PR
Gene name
radB
Protein name
DNA repair and recombination protein RadB
Names
Species
Thermococcus sibiricus (strain DSM 12597 / MM 739)
KEGG Pathway
tsi:TSIB_0108
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C6A0N1

Entry ID Method Resolution Chain Position Source
AF-C6A0N1-F1 Predicted AlphaFoldDB

No variants for C6A0N1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C6A0N1

No associated diseases with C6A0N1

3 regional properties for C6A0N1

Type Name Position InterPro Accession
domain AAA+ ATPase domain 19 - 177 IPR003593
domain DNA recombination and repair protein Rad51-like, C-terminal 2 - 217 IPR013632
domain DNA recombination and repair protein RecA-like, ATP-binding domain 1 - 155 IPR020588

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.

2 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLTTGSKNLD ALLGGGIDKG ILTQVYGPFA TGKTTLAMQI GLLNEGKVAY IDTEGGFSPE
70 80 90 100 110 120
RLAKMVESRG MDSNSTLQKF LIFEAFDFKE QKKTISNLKK IVNEKFSMIV VDSITNHYRV
130 140 150 160 170 180
EEKKSSMTTD LGKQLQVLLW LARKYNLAVI VTNQVYFDSK QNALKPLAEH IMGYKCKDIL
190 200 210 220
RLEKLRPGLR IAVLERHRFK PEGGIVHFEI TDKGIEDIEK IKSSQTTL