C5PCH4

PR
Gene name
GUF1
Protein name
Translation factor GUF1, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase
Species
Coccidioides posadasii (strain C735) (Valley fever fungus)
KEGG Pathway
cpw:CPC735_067510
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C5PCH4

Entry ID Method Resolution Chain Position Source
AF-C5PCH4-F1 Predicted AlphaFoldDB

No variants for C5PCH4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C5PCH4

No associated diseases with C5PCH4

7 regional properties for C5PCH4

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 467 - 552 IPR000640
domain Translational (tr)-type GTP-binding domain 65 - 245 IPR000795
domain Translation elongation factor EFTu-like, domain 2 266 - 336 IPR004161
domain Small GTP-binding protein domain 69 - 233 IPR005225
domain GTP-binding protein LepA, C-terminal 556 - 662 IPR013842
conserved_site Tr-type G domain, conserved site 104 - 119 IPR031157
domain Elongation factor 4, domain IV 469 - 548 IPR035654

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosome binding Binding to a ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGCLQSVRW LTTALRRPAP QLSCLPFQPF ASTSRLFSSC ASRAATAARK PPSELEQRIA
70 80 90 100 110 120
AIPIERFRNF CIVAHVDHGK STLSDRLLEL TGTIEPGSNK QVLDKLDVER ERGITVKAQT
130 140 150 160 170 180
CTMLYNYKGE DYLLHLVDTP GHVDFRAEVS RSYASCGGAL LLVDASQGVQ AQTVANFYLA
190 200 210 220 230 240
FAQGLELVPV INKVDLPSAD PDRALDQMKS SFELDVEQAV LVSAKTGLNV KQLLPTIVEQ
250 260 270 280 290 300
IPAPVGDHTK PLRVLLVDSW YDTYKGVILL IRVFDGEIKA GDQVVSFATG KKYIVGEVGI
310 320 330 340 350 360
MYPNQTPQTV LRAGQVGYVY FNPGMKQSQE AKIGDTYTKV GSEKLVEPLP GFEEPKAMVF
370 380 390 400 410 420
VAAYPVNSDD FPHLEESINQ LLLNDRSITV KKESSEALGG GFRLGFLGTL HCSVFQDRLQ
430 440 450 460 470 480
QEHGANIIIT PPSVPCKILW KSGEETVITS PIDFPDDDSS RMKVEEFQEP YVLTTLTFPQ
490 500 510 520 530 540
EYLGKVIELC EGNRGEQVSL EFFTATQVIL KYQLPLAQLV DDFFGKLKGL TKGYASLDYE
550 560 570 580 590 600
ESGWRKSNIV KLKLLVNKVP VDAVSRVVHT SQVARLGRQW VTKFKEHVDR QMFEIVIQAA
610 620 630 640 650 660
VGNKIVARES VKPFRKDVLA KLHASDVTRR RKLLEKQKEG RKRLQAVGNV IIEHKAFQAF
LSK