C5DE35

PR
Gene name
MAP2
Protein name
Methionine aminopeptidase 2
Names
MAP 2, MetAP 2, Peptidase M
Species
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
KEGG Pathway
lth:KLTH0C05962g
EC number
3.4.11.18: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C5DE35

Entry ID Method Resolution Chain Position Source
AF-C5DE35-F1 Predicted AlphaFoldDB

No variants for C5DE35

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C5DE35

No associated diseases with C5DE35

2 regional properties for C5DE35

Type Name Position InterPro Accession
domain Peptidase M24 101 - 407 IPR000994
binding_site Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site 187 - 203 IPR018349

Functions

Description
EC Number 3.4.11.18 Aminopeptidases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

2 GO annotations of biological process

Name Definition
protein initiator methionine removal The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDAIAKDAV NTSSEKEPVS ATPELKTSGS PDAAVSSGDK KKKKKKKKTN NIKNIALLYP
70 80 90 100 110 120
DEKYPEGEWM DYHQDFNLQR TTDEEKRYLT RDAENQQRWN DMRKGAEIHR RVRKNLQNKL
130 140 150 160 170 180
KPDMTLTEVV NIVENATRKF TGVDENGDHV DRPKSQGVGF PTGVSLNHCA AHFTPNAGDQ
190 200 210 220 230 240
TVLRYEDVMK VDIGVQVNGY IVDSAWTVAF DPKYDNLLQA VREATNTGVR EAGIDVRLTD
250 260 270 280 290 300
IGEAIQEVME SYEVELNGKT HQVKPCRNLC GHNIAPYRIH GGKSVPIVKN GDQTKMEEGE
310 320 330 340 350 360
HFAIETFGST GRGFVVPGGE VSHYAKSAEA DGLPAPSLSR AKSLLKTIDE NFGTLPFCRR
370 380 390 400 410
YLDRLGEDKY LFALNSLVKH GIVQDYPPLN DVQGSYTAQF EHTILLHPHR KEVVSRGEDY