C5CEA8
Gene name |
glyA |
Protein name |
Serine hydroxymethyltransferase |
Names |
SHMT, Serine methylase |
Species |
Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 1951) |
KEGG Pathway |
kol:Kole_1456 |
EC number |
2.1.2.1: Hydroxymethyl-, formyl- and related transferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C5CEA8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C5CEA8-F1 | Predicted | AlphaFoldDB |
No variants for C5CEA8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C5CEA8 | |||||
No associated diseases with C5CEA8
4 regional properties for C5CEA8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 8 - 19 | IPR001412 |
| domain | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain | 1 - 319 | IPR020058 |
| domain | Glutamyl-tRNA synthetase | 1 - 327 | IPR033910 |
| domain | Aminoacyl-tRNA synthetase, class I, anticodon-binding | 332 - 466 | IPR045462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.2.1 | Hydroxymethyl-, formyl- and related transferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycine hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycine biosynthetic process from serine | The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. |
| tetrahydrofolate interconversion | The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWELLAKGDP | EVYEIVMKEL | GRQEEGLELI | ASENFVSPAV | MEAMGSTLTN | KYAEGYPRRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YYGGCKFVDE | AEQLARERVK | KLFNCKYANV | QPHSGSQANM | AAYLAVANPG | DTIMGMSLSH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGHLTHGSPV | NFSGKLFNIV | SYGVDLETEV | LDYDEIERLA | LEHKPKIIIA | GGSAYSRIID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKRFREIADK | VGAYLIVDMA | HFAGLVAAGL | YPNPVDHAHI | VTSTTHKTLR | GPRGGLILTN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DEELYKAINK | AVFPGIQGGP | LMHVIAAKAV | AFGEALKDEF | KEYQMRIITN | AKALAKELEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGLRIVSGGT | DTHLFLVDLN | PKNVTGKAAE | KALESADITV | NKNTIPKETR | SPFVTSGIRI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GTPAVTTRGM | GESEMKVIAE | LIVKVIDNIQ | DEKGTIPEEI | REEVKKAVHE | LTEKFPLYKD |
| LT |