C5C878

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus)
KEGG Pathway
mlu:Mlut_01150
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C5C878

Entry ID Method Resolution Chain Position Source
AF-C5C878-F1 Predicted AlphaFoldDB

No variants for C5C878

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C5C878

No associated diseases with C5C878

4 regional properties for C5C878

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 223 - 399 IPR002314
domain Aminoacyl-tRNA synthetase, class II 172 - 409 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 107 IPR015866
domain Serine-tRNA ligase catalytic core domain 119 - 416 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDVKDLIEQ PEKYRASQEA RGEDASLVDR VVEADAARRS SIAGFEQLRA EQKAFGKRVA
70 80 90 100 110 120
QAKGEEKQAL LAEVKDLAAR VKEAESAAGA AEARLAELQR AFPNLIVDGV PAGGEDDFVV
130 140 150 160 170 180
LKEVGTPRDF AAEGFEPRDH LELGELLGAI DMERGAKVSG ARFSFLTGVG ARLELALMQL
190 200 210 220 230 240
GLDLALENGF VPVIPPTLVR PETMQGTGFD VEHDDEIYRL ERDDLYLVGT SEVALAGFHA
250 260 270 280 290 300
GEIMDVSAPV RYAGWSTCYR REAGSAGKDT RGIIRVHQFN KLEMFIYAAQ EDAEAEHARL
310 320 330 340 350 360
LAWEERMLGA IEVPYRVIDI AAGDLGLSAA RKFDCEAWVP TQGTYRELTS TSNCTTFQAR
370 380 390 400 410 420
RLNIRERVRT EDGSKGGTRM VATLNGTLAT TRWIVAILEN HQNADGSVTV PAALRPYLGG
MERFELV