C5BAR6

PR
Gene name
lysS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Edwardsiella ictaluri (strain 93-146)
KEGG Pathway
eic:NT01EI_3337
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C5BAR6

Entry ID Method Resolution Chain Position Source
AF-C5BAR6-F1 Predicted AlphaFoldDB

No variants for C5BAR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C5BAR6

No associated diseases with C5BAR6

2 regional properties for C5BAR6

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 385 - 393 IPR018039
domain Intermediate filament, rod domain 88 - 399 IPR039008

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEQQQQGAE QALDLNNEMQ ARREKLAALR KEGIAFPNDF RRDTTSDKLH SLYDGKSKEE
70 80 90 100 110 120
LEALNVEVSV AGRMMTRRIM GKASFVTLQD MGGRIQLYVA RDDLKDDVYS EQFKKWDLGD
130 140 150 160 170 180
IIGARGTLFR TQTGELSIHC HSIHLLTKAL RPLPDKFHGL SDQETRYRQR YLDLIANESS
190 200 210 220 230 240
RETFRTRSKI LAAIRNFMVN KGFMEVETPM MQVIPGGASA RPFITHHNAL DIDMYLRIAP
250 260 270 280 290 300
ELYLKRLVVG GFERVFEINR NFRNEGVSPR HNPEFTMMEL YMAYADYKDL IVLTEELFRT
310 320 330 340 350 360
ISQDVLGSSV VQYGDQTFDF GKPFIKMSMK EAICHYRPDI ASADLDDMDK ACKIAESLGI
370 380 390 400 410 420
KIEKSWGLGR VQCEIFDETA ESQLIQPTFI TEYPAEVSPL ARRNDDNPFI TDRFEFFIGG
430 440 450 460 470 480
REIGNGFSEL NDAEDQAERF QDQVKAKDAG DDEAMFYDED YVTALEHGLP PTAGLGVGID
490 500
RMMMLFTNSH TIRDVILFPA MRPQK