C5B850
Gene name |
pheS |
Protein name |
Phenylalanine--tRNA ligase alpha subunit |
Names |
Phenylalanyl-tRNA synthetase alpha subunit, PheRS |
Species |
Edwardsiella ictaluri (strain 93-146) |
KEGG Pathway |
eic:NT01EI_1890 |
EC number |
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C5B850
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C5B850-F1 | Predicted | AlphaFoldDB |
No variants for C5B850
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C5B850 | |||||
No associated diseases with C5B850
4 regional properties for C5B850
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphoglucose isomerase, conserved site | 260 - 273 | IPR018189-1 |
| conserved_site | Phosphoglucose isomerase, conserved site | 486 - 503 | IPR018189-2 |
| domain | Phosphoglucose isomerase, SIS domain 1 | 116 - 279 | IPR035476 |
| domain | Phosphoglucose isomerase, SIS domain 2 | 326 - 507 | IPR035482 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.20 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| phenylalanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phenylalanyl-tRNA aminoacylation | The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHLAELVAQ | AKAAVESAQD | VAALDSVRVE | FLGKKGHLTL | QMTSLRNLPA | EERPAAGAVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQAKQEVQEA | LNARKAALES | VALNARLAEE | TIDVSLPGRR | MENGGLHPVT | RTIERIESFF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SELGFAVATG | PEIEDDYHNF | DALNIPAHHP | ARADHDTFWF | DATRLLRTQT | SGVQIRTMQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QQPPIRIIAP | GRVYRNDYDQ | THTPMFHQME | GLIVDKDISF | TNLKGTLHDF | LRNFFEQDLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IRFRPSYFPF | TEPSAEVDVM | GKNGKWLEVL | GCGMVHPNVL | RNVGIDPQVY | SGFAFGMGME |
| 310 | 320 | ||||
| RLTMLRYGVT | DLRAFFENDL | RFLKQFK |