C5A1W0

PR
Gene name
truD
Protein name
Probable tRNA pseudouridine synthase D
Names
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D
Species
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
KEGG Pathway
tga:TGAM_1877
EC number
5.4.99.27: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

325-400 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C5A1W0

Entry ID Method Resolution Chain Position Source
AF-C5A1W0-F1 Predicted AlphaFoldDB

No variants for C5A1W0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C5A1W0

No associated diseases with C5A1W0

2 regional properties for C5A1W0

Type Name Position InterPro Accession
domain Pseudouridine synthase, TruD, insertion domain 158 - 378 IPR011760
conserved_site Pseudouridine synthase TruD, conserved site 80 - 93 IPR020119

Functions

Description
EC Number 5.4.99.27 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYREFFSQF RHLSEKPGIG GKIKILPEDF VVIEDPLPQI FEGRKHAIFL LKKRNWDTMA
70 80 90 100 110 120
VIKEIAKRAG ISHRDIGFAG TKDRHAVTYQ YISVPAGAKE KVESIQIRDV ELRFVSYGRF
130 140 150 160 170 180
IKLGHLLGNR FRIIIRDVEG SAFDRTKEII RELREKGGFP NYFGYQRFGE RRVVNHLIGK
190 200 210 220 230 240
LLLQGEFDEA ARLFLGYADG SMEGDEARRN FWETEDVDRA LEEFPRFLRY ERTLLYTYKK
250 260 270 280 290 300
TGSWKKAFLS LPLPIMRIFI HAYQSYLFNL YLSRRIEELP LNEPLVGDIV VQVKGGIPYR
310 320 330 340 350 360
DRTYRVTETN LNFVREKVKR GEAMVSGPLF GFAMRRAKGI PGELEEEILE GEGITLDAFK
370 380 390 400 410
KLPKPMAEPG RRRELLIRPI GLTYGYLPET GMCFRFFLPK GVYATSVLRE IMKDH