C4Z417

PR
Gene name
mutS2
Protein name
Endonuclease MutS2
Names
Species
Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4) (Eubacterium eligens)
KEGG Pathway
eel:EUBELI_01853
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

570-735 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4Z417

Entry ID Method Resolution Chain Position Source
AF-C4Z417-F1 Predicted AlphaFoldDB

No variants for C4Z417

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4Z417

No associated diseases with C4Z417

4 regional properties for C4Z417

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 322 - 507 IPR000432
domain Smr domain 709 - 787 IPR002625
domain DNA mismatch repair protein MutS, core 9 - 309 IPR007696
domain MutS2 and Smr-associated SH3 domain 637 - 677 IPR046893

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNKKSLSTLE FYKITDQLVS YACCDGAKKI LRNLKPMTDI TDINLRLNET NDALSRIFQK
70 80 90 100 110 120
GTVDFSQTKD IRASVARLKV GSSLNISELL NISAILSCAK HVKDYYEHRE DSISGMLENL
130 140 150 160 170 180
ATVDALNSQI KKCIISEDEI SDDASSNLRS IRRSKSIAND RIHSELNKLL NSPTYRTYLQ
190 200 210 220 230 240
DYVITTRQGR YCLPVKAEYK SAFPGMIHDQ SSTGSTLFIE PAAVVKLNND IRELELKEAA
250 260 270 280 290 300
EIEVILADLS AKAGEHTEEL LCDYEILVEL DCIFAKAQLA RHMHASRPVM NTSGIINIKK
310 320 330 340 350 360
GRHPLIESHT VVPIDIYLGT DFKLLIITGP NTGGKTVSLK TVGLLTLMAQ SGLFIPALDH
370 380 390 400 410 420
SDIAVFKNIY ADIGDEQSIE QSLSTFSSHM TNTVKILKEA DENCLVLFDE IGAGTDPTEG
430 440 450 460 470 480
AALAIAILND LKMRGVTTMA TTHYSEIKLY ALSTEGVENA SCEFDVESLR PTYRLLIGIP
490 500 510 520 530 540
GKSNAFAISK KLGLPDYILS DASERLNAED VHFEDIVSDL EHARISLEKE QAEVESYKAE
550 560 570 580 590 600
IASLKEKLQA KNERLDERTD NIIRKANEQA AAILKDAKDF ADETIKAMNK HGMTVAELEK
610 620 630 640 650 660
HRTAVREKMN KNQAKLKVEP AKVKAHKAHD ISEFKTGMHV KVLTMNVSGT VSAIHPAKKQ
670 680 690 700 710 720
VTVQVGALST KIDIKNLEIL SDYKEPKEAP SKAAGGSGKI KMSKSAGIST EINLLGCTVD
730 740 750 760 770 780
EAVARLDKYL DDAYIARIPQ VRIVHGKGTG ALRNGVTAYL RGVPYIKSFR LGEIGEGDAG
VTIVDFK