C4YMW2

PR
Gene name
THI5
Protein name
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Names
HMP-P synthase, Hydroxymethylpyrimidine phosphate synthase, Thiamine biosynthesis protein 5, Thiamine pyrimidine synthase
Species
Candida albicans (strain WO-1) (Yeast)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

282-339 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for C4YMW2

Entry ID Method Resolution Chain Position Source
4ESW X-ray 160 A A/B 1-339 PDB
4ESX X-ray 220 A A/B 1-339 PDB
AF-C4YMW2-F1 Predicted AlphaFoldDB

No variants for C4YMW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4YMW2

No associated diseases with C4YMW2

1 regional properties for C4YMW2

Type Name Position InterPro Accession
domain SsuA/THI5-like 16 - 238 IPR015168

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl- + N(6)-(pyridoxal phosphate)-L-lysyl- = (2S)-2-amino-5-hydroxy-4-oxopentanoyl- + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTNKITFLL NWEAAPYHIP VYLANIKGYF KDENLDIAIL EPSNPSDVTE LVGSGKVDMG
70 80 90 100 110 120
LKAMVHTLAA KARGFPVTSI GSLLDEPFTG ICYLEGSGIT SDFQSLKGKR IGYVGEFGKI
130 140 150 160 170 180
QVDELTKHYG MTPDDYVAVR CGMNVAKYIL EGTIDCGIGI ECIQQVELEE ALKEQGKDSN
190 200 210 220 230 240
DAKMLRIDKL AELGCCCFCT ILYIANDKFI AENPQAVKKF LKAIKRATDY MLAHPREAWA
250 260 270 280 290 300
EYGNFKPTMQ TDLNTKKFQR CYAYFSESLY NVHRDWRKVN NYGKRLDILP ENYVPNYTNE
310 320 330
YLSWPEPKEV DDPEKAQDLM LKHQEECKTC GGYKRLVLA