C4V819

PR
Gene name
NCER_100619
Protein name
Probable glutamine--tRNA ligase
Names
Glutaminyl-tRNA synthetase, GlnRS
Species
Nosema ceranae (strain BRL01) (Microsporidian parasite)
KEGG Pathway
nce:NCER_100619
EC number
6.1.1.18: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

125-200 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4V819

Entry ID Method Resolution Chain Position Source
AF-C4V819-F1 Predicted AlphaFoldDB

No variants for C4V819

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4V819

No associated diseases with C4V819

3 regional properties for C4V819

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 201 - 212 IPR001412
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 194 - 513 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 517 - 678 IPR020059

Functions

Description
EC Number 6.1.1.18 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamine-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

1 GO annotations of biological process

Name Definition
glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFDVESLLKK LNVSEDKKEN ILQKEQLKKN LETLYTNFDT DNKLLFTLAC TAPKKIDILI
70 80 90 100 110 120
FGILINENVI KNDATLRASM KFAIKNTDVT YEELKDFILK NTKSKEEVSE IINKACLSGK
130 140 150 160 170 180
SKKEVYIILK NKLPFEDSKY LMDEVNKFEI DTSKSKKVKD WLEEGEVSML HKPGDNPQLN
190 200 210 220 230 240
EKILKDHLER TGGKVVTRFP PEPNGILHIG HAKAINLDFG YAEKYNGICY LRFDDTNPRN
250 260 270 280 290 300
EEDYYFESII EDVKWLGFEP YAITSSSKYF GDMCELAEKL ILKDKAYICE LSNEELKKRR
310 320 330 340 350 360
RMLSEAFETD KDKSIEELGL ILSPYRNREI SENLKIFREM VEKKHKEGDY TLRFKMDIRS
370 380 390 400 410 420
KNPMMFDLVG MRIIDCDHVV TKDKYNLYPS YEFALCVSDS LEDVTHSFCT REFFTRQESY
430 440 450 460 470 480
KWLLDALEIY KPVQWEFSRL NISNTVLSKR KIVPLKKYGI ELDDPRLYTI KGMRRRGIPP
490 500 510 520 530 540
QAINNFVKSL GITYAETIID NKKFESFIRD ELNKTTQRVM CVMDPLKIYI RNAKEQEISI
550 560 570 580 590 600
PNSNQKIIFK PYIYIEKSDF KMEDDDKDFL RFTPNQSVGL YMFGAIKFIK FDNDMIIAEL
610 620 630 640 650 660
TNETPKKFIH WVSCDSIKVT IRLYDPLFRS FNPEEGNYLD NINLDSLKTV VGYCDDRIKG
670 680 690
CEVEDKFQFQ RVGYFCVDPD TTPENIVFNR IITLI