C4R7S7

PR
Gene name
GET1
Protein name
Golgi to ER traffic protein 1
Names
Guided entry of tail-anchored proteins 1
Species
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KEGG Pathway
ppa:PAS_chr4_0403
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4R7S7

Entry ID Method Resolution Chain Position Source
AF-C4R7S7-F1 Predicted AlphaFoldDB

No variants for C4R7S7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4R7S7

No associated diseases with C4R7S7

No regional properties for C4R7S7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for C4R7S7

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Golgi apparatus membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPFSILLTL TLIILAQNAV RIVGKSQIHQ SIWNLYLRYS NDQQILKLRN LKAESYDVYK
70 80 90 100 110 120
QRSNTSAQDE YAKWTKLNRK YDQLQTEIKA VSDQVSQQQQ AIEKYLGLAI SVTTTLPLWL
130 140 150 160 170 180
FRFKYRKQPL FYFPKDTFPS YLEWILSFPS VPQGSIGIMF WILLLNKFVS NLEFIVKTFS
190
TKVEKPVPIV KVEDLSPK