C4QWJ4

PR
Gene name
MDM10
Protein name
Mitochondrial distribution and morphology protein 10
Names
Mitochondrial inheritance component MDM10
Species
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
KEGG Pathway
ppa:PAS_chr1-1_0247
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4QWJ4

Entry ID Method Resolution Chain Position Source
AF-C4QWJ4-F1 Predicted AlphaFoldDB

No variants for C4QWJ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4QWJ4

No associated diseases with C4QWJ4

2 regional properties for C4QWJ4

Type Name Position InterPro Accession
domain Mitochondrial adapter protein MCP1, transmembrane domain 68 - 167 IPR012472-1
domain Mitochondrial adapter protein MCP1, transmembrane domain 182 - 275 IPR012472-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Multi-pass membrane protein
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
mitochondrial outer membrane translocase complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.
mitochondrion-endoplasmic reticulum membrane tethering The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEYMEYLEQ CFAKNSQWDY NNLYEHVLDS SASILQFKIP HGFKFSVSSS SSPYNYNSIS
70 80 90 100 110 120
FENRGKGRLN GSLAYFYTTQ ELSNYKTSKN IPLQDVIDSY RLVNIPKNDR SYTDNEESKR
130 140 150 160 170 180
PWLLYGRMYL PSQSMEAMAI KRLTANTQLM LKGVNILNPT PTPFNNKLTS LSFYLQSNYY
190 200 210 220 230 240
KWSREAIFLS SDALFGLRFL YNFGNSTNPQ CTPSIDSNNI STLSLGTELW YGAMNMTPGL
250 260 270 280 290 300
STTLRYTSFS VTGNPLTFTL ACNPILGSVS TTYSIKTNVF TTLCSKFDFN FYSYESDLTI
310 320 330 340 350 360
GCDLWRFGNN EDVPDSNPTP LPSKERELFI PLHDHQLVFP EQEKAKTISN EPKDYESDLL
370 380 390 400 410 420
LKFLEIQGIK TARQSVATIN NFTQKIKNAP FTSALKLNTS LKNHTVNLMW EGKYNDFLLS
430 440
TGCSLNLDLK RPNVDGFGLQ IQYSS