C4M6U3

PR
Gene name
EHI_054180
Protein name
Protein SEY1 homolog 2
Names
Species
Entamoeba histolytica
KEGG Pathway
ehi:EHI_054180
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4M6U3

Entry ID Method Resolution Chain Position Source
AF-C4M6U3-F1 Predicted AlphaFoldDB

No variants for C4M6U3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4M6U3

No associated diseases with C4M6U3

7 regional properties for C4M6U3

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 723 - 812 IPR000640
domain Translational (tr)-type GTP-binding domain 17 - 344 IPR000795
domain Translation elongation factor EFTu-like, domain 2 395 - 470 IPR004161
domain Small GTP-binding protein domain 20 - 164 IPR005225
domain Translation elongation factor EFG/EF2, domain IV 604 - 721 IPR005517
conserved_site Tr-type G domain, conserved site 58 - 73 IPR031157
domain Elongation Factor G, domain II 487 - 548 IPR041095

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDEVSPTKHF TSKPLLPTKT PRDKAISHYV NALNSPRNVV KTETPECGIQ IIDGDGNFAS
70 80 90 100 110 120
TDTRERPSLK NYILSKPEFL KRGMDYNAVG ILGAQSSGKS TLLNYLFNTK FRILNEVMGR
130 140 150 160 170 180
SRTTHGVWMA LSGKESNIVV FDLEGTDGSA REDDYSFERK TSLFSLSVCS VLMVNLWSHD
190 200 210 220 230 240
VGRFQASNMS LLKTVFELNL QLFVKEETPK TLIVFVIRDR EADTPFDQIE RDIMEDIMRI
250 260 270 280 290 300
WDTVIPPEEF INSPINRFFD FQFTSLPHYE HFYENFVEEV NLMKKKFDPK NKDTYFLPQY
310 320 330 340 350 360
NKEIPADGLS CFCEQIWETI KDNKDLDLPS QREMLSRYRC TEISNQIYKE FNDSIKGEMK
370 380 390 400 410 420
ILKKGNIIED FKKVFTKQID AALERYKEVT ERYMETIVEE IEEQLKKQLC GLVESLFERQ
430 440 450 460 470 480
AELMEKAIGK RVKGEFTIIR NEYALLYNKK EFNPMKYQKY SQELSRTKAV IERDWRKQFD
490 500 510 520 530 540
DSVPKFLAEK TKEKFNSVCK DIGIAYEDSV SKMTEVMKQH FGDYLESTIK PKITPYLEAC
550 560 570 580 590 600
KKDMWKNIRN VINIQFTNGF NKLEEGFKTC SNMNKDTIEE EIKKSKTDIL NSIKELVIKR
610 620 630 640 650 660
KIELPYLLER KFNNMFRFDN KGLPRKWEPT DDVDTLYFAA RDETEDILDM YCYFRIEESD
670 680 690 700 710 720
DQYKFTINYR DGDLPSESIE TLPKGADEEK VILNHEERKE LIETLNGFFE KGYLIALREK
730 740 750 760 770 780
ENSEIKYQIP LYLIVLVVFF GFDEFIAILT NPLLFILTLI IGGGVYIGYK LNLGGVAKNY
790 800 810 820
IQYLLSMSLS STMEYLRTIP FFTPLIDKVW PKDDNNTEET QEEIK