C4M572

PR
Gene name
EHI_111740
Protein name
tRNA (guanine(37)-N1)-methyltransferase
Names
M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog
Species
Entamoeba histolytica
KEGG Pathway
ehi:EHI_111740
EC number
2.1.1.228: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4M572

Entry ID Method Resolution Chain Position Source
AF-C4M572-F1 Predicted AlphaFoldDB

No variants for C4M572

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4M572

No associated diseases with C4M572

5 regional properties for C4M572

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatases domain 343 - 390 IPR000387
domain Protein-tyrosine phosphatase, catalytic 319 - 470 IPR003595
domain GRAM domain 29 - 142 IPR004182
domain Myotubularin-like, phosphatase domain 150 - 537 IPR010569
active_site Protein-tyrosine phosphatase, active site 372 - 382 IPR016130

Functions

Description
EC Number 2.1.1.228 Methyltransferases
Subcellular Localization
  • Mitochondrion matrix
  • Nucleus
  • Cytoplasm
  • Predominantly in the mitochondria and in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
tRNA (guanine(37)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

3 GO annotations of biological process

Name Definition
mitochondrial tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKEQLPELK YINVNDFNIN EKVIGIPVQT NEVAKYMKMF KGLCYNRIKT KCVIPYNSER
70 80 90 100 110 120
MILLETPLKE QTQKLIQDNH LKTVETEVPL TIKNFNVNEI MKRYINKNIQ LPSSFETVGT
130 140 150 160 170 180
LAHMNLKEEQ MEFKYIIGEA FLIKNYPRIQ TVITKTAEIS NEFRTFPLEV IAGIPNTEVT
190 200 210 220 230 240
VICHGVKFVL DYAQCYWNTR LETEHIRIIN QMKAGEILCD AFAGVGPFAI PAALKGVKVY
250 260 270 280 290 300
ANDLNPTAVK YMRINAVNNK TTIECDNMDA RDYLRKIVLE KHIQPNYILM NLPATAIEFL
310 320 330 340 350 360
DCIPELYLQH CMIHCYGFSP LPNAEDLKKK AFELLKGEYP ITIREVRDVA PKKVMYCLSI
370 380
FIESTKHLTS GNNVPEAKKT LN