C4L8X2

PR
Gene name
truB
Protein name
tRNA pseudouridine synthase B
Names
tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase
Species
Tolumonas auensis (strain DSM 9187 / TA4)
KEGG Pathway
tau:Tola_2244
EC number
5.4.99.25: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4L8X2

Entry ID Method Resolution Chain Position Source
AF-C4L8X2-F1 Predicted AlphaFoldDB

No variants for C4L8X2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4L8X2

No associated diseases with C4L8X2

3 regional properties for C4L8X2

Type Name Position InterPro Accession
domain Pseudouridine synthase II, N-terminal 34 - 181 IPR002501
domain tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal 253 - 310 IPR015240
domain tRNA pseudouridylate synthase B, C-terminal 182 - 249 IPR032819

Functions

Description
EC Number 5.4.99.25 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRRRRFKGR DVHGIILLDK PGGITSNDAL QQVKRIYNAA KAGHTGALDP LATGMLPICF
70 80 90 100 110 120
GEATKFSQFL LDADKRYQVT ARLGVRTDTS DSEGSVVSVR PVDVSEDQLA QALDKFRGDI
130 140 150 160 170 180
MQVPSMFSAL KHQGRPLYEY AREGIEIERE ARPITIYSLE LKAFSGEEIS LEVHCSKGTY
190 200 210 220 230 240
IRSLIDDLGE LLGCGAHVIQ LRRTQVACYP NDKMLNLEKL NEILDECREQ GVPPRERLDQ
250 260 270 280 290 300
YLLPMDSAVY SLPEVNMPPV LAAYVTQGQA VMVPHAPIEG FVRMTVGPEA EFIGVGEIDD
310 320
DGKVAPRRLV RIGGDMPDAE EQAE