C4KHR4

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Sulfolobus islandicus (strain M164 / Kamchatka #3)
KEGG Pathway
sid:M164_1527
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4KHR4

Entry ID Method Resolution Chain Position Source
AF-C4KHR4-F1 Predicted AlphaFoldDB

No variants for C4KHR4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4KHR4

No associated diseases with C4KHR4

4 regional properties for C4KHR4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 242 - 421 IPR002314
domain Aminoacyl-tRNA synthetase, class II 199 - 431 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 7 - 108 IPR015866
domain Serine-tRNA ligase catalytic core domain 121 - 438 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWSILEFLR KNPEELKNNL KRRAIDVSLV DKAVELDKKW RQVLQEVERL RHQHNVLSSQ
70 80 90 100 110 120
IPKLSGEERK KKIEESKNLL KILEDKEKEL EKIEVERDRL LSSLPNLVAD DVPNGPDDSY
130 140 150 160 170 180
NIPIKFWGKF KVYEGDVEEF LRQTKDANVN YEIIKWKPKG HAEMLEDVLH LGNTLKAAEI
190 200 210 220 230 240
AGSRFYYLFN DIVWLDFALL LFAIDYITQQ GYTLVLPPYM LRGEVIQSVI DLDTFKDAIY
250 260 270 280 290 300
KIENEDLYLI ATAEHSIAAM FFKEEIEKDK LPLKFAGISP AFRKEAGAAN KDLKGIFRVH
310 320 330 340 350 360
QFHKVEQFIF STPEDSWKYH AELITNAESI FQQLELPYRI VNIASGDLGA CAAKKFDLEV
370 380 390 400 410 420
WMPAQAKFRE MVSCSNCTDW QAFRMKIRYV DRKNNKRGYV HTLNSTAIAS TRTITAILEN
430 440 450
YQREDGVVEV PKVLRKYLEI FPKAPKDYIY PLKNKII