C4K332
Gene name |
hemH |
Protein name |
Ferrochelatase |
Names |
Heme synthase, Protoheme ferro-lyase |
Species |
Hamiltonella defensa subsp Acyrthosiphon pisum (strain 5AT) |
KEGG Pathway |
hde:HDEF_0207 |
EC number |
4.98.1.1: Forming coordination complexes |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C4K332
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C4K332-F1 | Predicted | AlphaFoldDB |
No variants for C4K332
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C4K332 | |||||
No associated diseases with C4K332
4 regional properties for C4K332
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | 171 - 307 | IPR006151 |
| domain | Glutamyl-tRNA reductase, N-terminal | 6 - 156 | IPR015895 |
| domain | Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain | 321 - 418 | IPR015896 |
| conserved_site | Glutamyl-tRNA reductase, conserved site | 99 - 122 | IPR018214 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.98.1.1 | Forming coordination complexes |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ferrochelatase activity | Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| heme biosynthetic process | The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKSKLGVLL | VNLGTPDAPT | VPAIKRYLKQ | FLSDRRVIDT | PPILWWPLLR | GIVLPFRSRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VAKLYQSIWM | PEGSPLLVYS | DRQQKALAAR | LPDASVELAM | SYGSPSLGDA | INRLITQGII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLVILPLYPQ | YSATTCGSVW | DAVSGILKKY | RSLPSIYFIR | DYAQHPSYIN | ALKQSVARYF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKHGQPDKLL | LSFHGIPQRY | VRLGDDYPKR | CEDTYRALST | ALGLHNNKIM | MTYQSRFGWE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PWLTPYTDKT | LKSLPAKGIK | HIQVLCPGFS | ADCLETLEEI | KEQNKEIFLK | AGGKKFEYIP |
| 310 | |||||
| ALNDSPEQID | LLEQLVSLG |