C4JPW9

PR
Gene name
PAC1-2
Protein name
Nuclear distribution protein PAC1-2
Names
Lissencephaly-1 homolog 2, LIS-1 2, nudF homolog 2
Species
Uncinocarpus reesii (strain UAMH 1704)
KEGG Pathway
ure:UREG_04612
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C4JPW9

Entry ID Method Resolution Chain Position Source
AF-C4JPW9-F1 Predicted AlphaFoldDB

No variants for C4JPW9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C4JPW9

No associated diseases with C4JPW9

10 regional properties for C4JPW9

Type Name Position InterPro Accession
repeat WD40 repeat 99 - 182 IPR001680-1
repeat WD40 repeat 186 - 284 IPR001680-2
repeat WD40 repeat 280 - 339 IPR001680-3
repeat WD40 repeat 341 - 384 IPR001680-4
repeat WD40 repeat 384 - 458 IPR001680-5
conserved_site WD40 repeat, conserved site 220 - 234 IPR019775-1
conserved_site WD40 repeat, conserved site 262 - 276 IPR019775-2
repeat G-protein beta WD-40 repeat 220 - 234 IPR020472-1
repeat G-protein beta WD-40 repeat 326 - 340 IPR020472-2
repeat G-protein beta WD-40 repeat 367 - 381 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, spindle pole
  • Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule associated complex Any multimeric complex connected to a microtubule.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

1 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
microtubule sliding The movement of one microtubule along another microtubule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIGFWTWKS IKLSIAIPLM CSHVSSALRA ELGLDEEAFG TAAAKKYETL LEKKWTSIVR
70 80 90 100 110 120
LQKKIMDLES RNAALQTELA NLTPTALSKR HQDPASWLPR SVRHSLESHR DTINSIAFHP
130 140 150 160 170 180
IYSSLASCSD DCTIKIWDWE LGELERTVKG HTRAVLDVDY GGPRSSILLA SCSSDLSIKL
190 200 210 220 230 240
WDPADEYKNI RTLLGHDHSV GAVRFIPSGA SGTLSSGNLL VSASRDGTLR IWDVVTGYCV
250 260 270 280 290 300
KTLRGHTAWV RDVCPSFDGR FLLSAGDDMT TRLWNISGSN SDHKLTMLGH EHVIECCALA
310 320 330 340 350 360
PFASYQYLAA LTGLKAPPAS SAAEFMATGS RDKTIKLWDA HGRCLGTLIG HDNWVRALAF
370 380 390 400 410 420
HPGGKYLLSV SDDKTLRCWD LSQGGKCVKT LKDAHERFIT CLRWAPGIFK NVPGVSTRDA
430 440 450
NGESNGVLNT GLKGDTPDVQ VRCVIATGGV DKKLQVFAD