C3N6D0

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Sulfolobus islandicus (strain M1627)
KEGG Pathway
sim:M1627_1677
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

215-423 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C3N6D0

Entry ID Method Resolution Chain Position Source
AF-C3N6D0-F1 Predicted AlphaFoldDB

No variants for C3N6D0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C3N6D0

No associated diseases with C3N6D0

4 regional properties for C3N6D0

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 15 - 242 IPR001048
domain PUA domain 286 - 369 IPR002478
conserved_site Glutamate 5-kinase, conserved site 216 - 233 IPR019797
domain Glutamate-5-kinase domain 15 - 265 IPR041739

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQITREKWSK NFSEWFDWVL REGEFYDYGR YPVKGMGVWM PYGFKLRQNI ISIIRNLLDS
70 80 90 100 110 120
TGHEEVLFPL LIPEDLLSRE STHIKGFEEE VFWVTKGGSE DLDVKLALRP TSEVAITTME
130 140 150 160 170 180
NLWLKSYKQL PKKYYQIVSV FRYETKATRP MIRLREITTF KEAHTVHETY DDAQRQVEEA
190 200 210 220 230 240
IEIYKKIFNN LAIPYVLSER PEWDRFAGAL HTYAFDTIMP DGKVMQIGTV HHLGQNFSRA
250 260 270 280 290 300
LDFKIQKKDG SLDYPHQTSY GISDRAIASV IAIHGDDHGP ILPPSVAPIK VVVVPIPAKN
310 320 330 340 350 360
EEGTQQVMKY SVEICEMLNK NNITCVTDQD TEKTPGEKFY IWEIKGVPIR LEIGPRELAS
370 380 390 400 410 420
STVFIKRRDN LKSYTVKKEE VVNKVKEVLN EIQEDLRKRA WESLKSRIEY ANDIEKAKNL
430 440 450 460 470 480
LENNSGIVEV PWCGSKECGL KIEELTNARV LGYPIEDRKV NDKCVICKMN AKTVLRVAKT
Y