C3MJ22

PR
Gene name
hemL
Protein name
Glutamate-1-semialdehyde 2,1-aminomutase
Names
GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT
Species
Sulfolobus islandicus (strain LS215 / Lassen #1)
KEGG Pathway
sis:LS215_2116
EC number
5.4.3.8: Transferring amino groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-40 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C3MJ22

Entry ID Method Resolution Chain Position Source
AF-C3MJ22-F1 Predicted AlphaFoldDB

No variants for C3MJ22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C3MJ22

No associated diseases with C3MJ22

No regional properties for C3MJ22

Type Name Position InterPro Accession
No domain, repeats, and functional sites for C3MJ22

Functions

Description
EC Number 5.4.3.8 Transferring amino groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
glutamate-1-semialdehyde 2,1-aminomutase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

1 GO annotations of biological process

Name Definition
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKGRCTILN SEELWAQARQ LFAGGVNSPV RAAVKPFPFY VERGKGAYIY TVEGNKFIDY
70 80 90 100 110 120
VLGYGPLILG HSPESVKRKI IEQLEKGWLF GTPSKLEIEL AKKISSHIPS AQKIRFVNSG
130 140 150 160 170 180
TEATMAAIRL ARGYSKRSKI LKFSGNYHGA HDYTLVEAGS AATEYNVTTS DGIPMEIMKT
190 200 210 220 230 240
VEICEFNDLD CVDKKLRNED IAAALLEPIM GNAGVILPEK GFLSGLRELT KSYNSLLIFD
250 260 270 280 290 300
EVITGFRIDI GGAQSYYQIY PDITTLGKII GGGFPIGAVA GKAEIIDNFT PAGRVFNAGT
310 320 330 340 350 360
FNANPISMIA GIATIEELEK EYPYNIANKA SKTLVEELER LLKIKHTINH IGSMFQVFFG
370 380 390 400 410 420
IDKVRNYSDA KRANKEYYIK FHERLLKERV FIPPSQYETI FTSAAHEDDV VNDTIDKLAK
VIGELS