C3M9Z5

PR
Gene name
dnaE2
Protein name
Error-prone DNA polymerase
Names
Species
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
KEGG Pathway
rhi:NGR_c31860
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

868-941 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C3M9Z5

Entry ID Method Resolution Chain Position Source
AF-C3M9Z5-F1 Predicted AlphaFoldDB

No variants for C3M9Z5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C3M9Z5

No associated diseases with C3M9Z5

5 regional properties for C3M9Z5

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 8 - 78 IPR003141
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 973 - 1047 IPR004365
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 279 - 533 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 779 - 886 IPR029460
domain DNA polymerase III alpha subunit finger domain 536 - 706 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleic acid binding Binding to a nucleic acid.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGEPTFHEL GARTNFSFLE GAAPAEEMIV FAKKAGLSGL GVADRNSVAG VVRAHAKAKV
70 80 90 100 110 120
EDYPFQPGAR LVFADATPDI LAYPKNRRGW GHLCRLLSVG NLRAKKGDCT LYLADLLEWQ
130 140 150 160 170 180
EDLLLIVMPG EGRPQPEILE ALLEKLKASA GNRLYLGLAP RYDSFDRHDF AVLATVARSL
190 200 210 220 230 240
DVRLLATNDA LYHDPHYRPL ADVVTAIREH VPIASAGFLL QKNAERHLKG PKEMVRLFRD
250 260 270 280 290 300
YPEAIVNANK FFKRLSFSLD ELSHQYPDEN AEGETPAESL RRLVAEGALE RYPSGVPEKV
310 320 330 340 350 360
TRQIEYELEL IHDKKYEPYF LTVHKLVKFA RSVNILCQGR GSAANSSVCF CLGITDVDPQ
370 380 390 400 410 420
KFTLLFDRFL SRDRDEPPDI DVDFEHERRE EVIQYIYRTY GKEHAGLTAA VISYRSRSAG
430 440 450 460 470 480
REVAKAFGLS EDVQSALVSS VWGWGTSPFT EEQAKGAGLD MADPLTRRVL AYASLLMNFP
490 500 510 520 530 540
RHLSQHVGGF VITRDRLDEV VPIMNTAMPD RYMIEWDKDD LDQLKILKVD VLALGMLTCL
550 560 570 580 590 600
ARAFRFLEVH YGKPKTLAEL YEDQQAAVYD MICRADTVGV FQIESRAQMS MLPRLRPREM
610 620 630 640 650 660
YDLVIEVAIV RPGPIQGNMV HPYLKRREAQ RKGEPVDYPS PELKAVLERT LGVPLFQEQA
670 680 690 700 710 720
MQIAITAAGF SPSEADRLRR AMATFKRTGT IHTFERKMID GMVRNGYERE FAERCFNQIK
730 740 750 760 770 780
GFGEYGFPES HAASFASLVY ASSWFKAYYP DIFCAALLNS QPMGFYAPAQ LVRDAREHGV
790 800 810 820 830 840
RILPVDVNHS DWDALLEGEA MFRKEAIDPR HGEMRDVIRS GKAVRLGFRL VKGLRQPDME
850 860 870 880 890 900
ALVARRGEGY RSVHDLWLRS GLTRAVLERL ADADAFRSIG LDRRRALWAV KALNEQSAVE
910 920 930 940 950 960
RLPLFDGAGS TDLQVEPAVA LPDMAAGEHV IHDYRYLTLS LKAHPVSFMR GDFARMGILS
970 980 990 1000 1010 1020
SRDLARTPAG RRVTVAGLVL VRQRPGSANG VIFMTIEDET GVANIIVWEK TFQKYRPQVM
1030 1040 1050 1060 1070 1080
GSRLVKVRGR LQSESGVIHV VAEYMEDMTP MLGLLRNEAR RFGANDRADE ALRPTADARD
1090 1100 1110
KKALRQLRPA PPAQEGLETS EAGSAVAEVM PKGRNFH