C1L2E3

PR
Gene name
rph
Protein name
Ribonuclease PH
Names
RNase PH, tRNA nucleotidyltransferase
Species
Listeria monocytogenes serotype 4b (strain CLIP80459)
KEGG Pathway
lmc:Lm4b_01243
EC number
2.7.7.56: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for C1L2E3

Entry ID Method Resolution Chain Position Source
AF-C1L2E3-F1 Predicted AlphaFoldDB

No variants for C1L2E3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for C1L2E3

No associated diseases with C1L2E3

3 regional properties for C1L2E3

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 11 - 139 IPR001247
domain Exoribonuclease, phosphorolytic domain 2 160 - 225 IPR015847
conserved_site Ribonuclease PH, conserved site 116 - 128 IPR018336

Functions

Description
EC Number 2.7.7.56 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
tRNA binding Binding to a transfer RNA.
tRNA nucleotidyltransferase activity Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.

3 GO annotations of biological process

Name Definition
rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRVDGRESNA LRNIEVTPDY LMHPEGSVLI ASGNTKVICS ASVETKVPPF MRGEGRGWIS
70 80 90 100 110 120
AEYSMLPRAT NTRNIRESSK GKVTGRTMEI QRLIGRALRA VVDLDALGER TIWLDCDVIQ
130 140 150 160 170 180
ADGGTRTASI TGAFIAMVMA IAKLDEAVPF AKFPVKDFLA ATSVGVLEEG GTVLDLNYVE
190 200 210 220 230 240
DSAAQVDMNI IMTGSGAFVE LQGTGEEATF SETELAELIA LGKKGISELI EIQKETLGDK
VTARIKGE